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Psoriatic skin-sensitive degradable mesoporous zinc phosphate microsphere as a photosensitizer in photodynamic therapy for anti-psoriasis.
Eur J Pharm Sci
February 2025
College of Pharmacy and Medical Technology, Putian University, Putian 351100, Fujian, China; Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine (Putian University), Putian 351100, Fujian, China.
Blue light will be a promising alternative for photodynamic therapy in psoriasis, but the photosensitizer in vivo remains unexplored. Mesoporous zinc phosphate microparticle (MZP) was synthesized successfully in this study, as evidenced by XPS, XRD, and nitrogen adsorption experiments. Its psoriatic skin-sensitive property was corroborated by SEM and the higher cumulative release rate of that impregnated with curcumin (Cur) and glycyrrhizic acid (GA), namely Cur-GA-MZP, at pH 5.
View Article and Find Full Text PDFCardiodermatology: the heart of the connection between the skin and cardiovascular disease.
Nat Rev Cardiol
November 2024
Leaon H. Charney Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York City, NY, USA.
Article Synopsis
- The skin and cardiovascular systems are interconnected, with various cardiovascular diseases linked to specific skin manifestations.
- Inflammatory skin conditions, like psoriasis, can lead to serious cardiovascular and metabolic health issues, while some cardiovascular medications may cause adverse skin reactions.
- This review emphasizes the importance of integrating dermatology and cardiology insights for effective diagnosis and management of patients experiencing both skin and cardiovascular problems.
Unveiling ferroptosis: a new frontier in skin disease research.
Front Immunol
October 2024
Science Education Department, Chengdu Xinhua Hospital Affiliated to North Sichuan Medical College, Chengdu, China.
Article Synopsis
- Ferroptosis is a unique type of regulated cell death that differs from apoptosis, necrosis, and autophagy, and is gaining attention for its involvement in skin diseases.
- The review explores how ferroptosis, characterized by iron buildup and lipid damage, affects several skin conditions like psoriasis, dermatitis, and melanoma, while also comparing it to other cell death processes.
- It discusses the role of ferroptosis in five skin diseases and examines potential therapies targeting ferroptosis to improve skin disease management and treatment.
Effects of metal oxide nanoparticles on healthy and psoriasis-like human epidermal keratinocytes in vitro.
Arch Toxicol
November 2024
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Ave, Singapore, 639798, Singapore.
The use of metal oxide nanoparticles (NPs) in skincare products has significantly increased human skin exposure, raising safety concerns. Whilst NP's ability to penetrate healthy skin is minimal, studies have demonstrated that metal oxide NPs can induce toxicity in keratinocytes through direct contact. Moreover, NP's effect on common skin disorders like psoriasis, where barrier impairments and underlying inflammation could potentially increase NP penetration and worsen nanotoxicity is largely unstudied.
View Article and Find Full Text PDFAggregation-Induced Emission-Active Photosensitizer-Mediated Photodynamic Therapy for Anti-Psoriasis.
Research (Wash D C)
June 2024
Dongguan People's Hospital Biobank, Affiliated Dongguan Hospital, Southern Medical University, Dongguan, Guangdong 523059, China.
Hyperproliferative keratinocytes and subcutaneous inflammation contribute to the characteristic symptoms of psoriasis, including erythema, scales, or scaly plaques on the skin. These symptoms significantly affect patients' quality of life and cause severe physical and psychological distress. However, current treatment strategies have limited therapeutic effect and may lead to adverse side effects.
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