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Proteomic and metabolomic analysis of GH deficiency-induced NAFLD in hypopituitarism: insights into oxidative stress.
Front Endocrinol (Lausanne)
June 2024
Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Objective: Individuals with hypopituitarism (HPs) have an increased risk of developing non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) due to growth hormone deficiency (GHD). We aimed to investigate the possible mechanisms underlying the relationship between GHD and NAFLD using proteomic and metabolomic insights.
Methods: Serum metabolic alternations were assessed in male HPs using untargeted metabolomics.
In Reply to the Letter to the Editor Regarding "Risk Factors Related to Transient Diabetes Insipidus Development Following Transsphenoidal Pituitary Adenoma Resection: A Multicentric Study".
World Neurosurg
May 2024
Department of Neurosurgery, LINT, School of Medicine, National University of Tucuman, Tucuman, Argentina.
Pituitary macroadenoma apoplexy as a rare complication of Bruton tyrosine kinase inhibitor in chronic lymphoid leukaemia.
Chin Neurosurg J
October 2023
East Suffolk and North Essex NHS Foundation Trust, Colcchester, UK.
Background: Pituitary apoplexy is a neurosurgical emergency and is a known yet rare complication of pituitary macroadenoma. Patients typically present with visual field defects, headache and altered sensorium. There are multiple risk factors for this complication and a thorough drug history is essential to exclude iatrogenic causes of disease.
View Article and Find Full Text PDFPituitary apoplexy during pregnancy with transsphenoidal resection and intraoperative fetal monitoring: A case report.
Case Rep Womens Health
September 2023
Sanford Health System, Department of Neurosurgery, 2301 25th St S, Fargo, ND 58103, USA.
Introduction: Prolactinomas resulting in pituitary apoplexy are an uncommon obstetrical complication. The hemorrhage can cause compression and necrosis of the pituitary gland as well as the optic chiasm, necessitating surgical intervention.
Case: A 35-year-old woman, G0, presented for an infertility consult with a prior diagnosis of polycystic ovarian syndrome.
Effectiveness of Leksell gamma knife hypophysectomy on cancer-related intractable pain - a single-center experience.
Neuro Endocrinol Lett
December 2022
Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic.
Objectives: Hypophysectomy is a method used in analgesia in patients with painful bone metastases. The pain relief after this procedure is not pathophysiologically fully understood. In only a few studies Leksell gamma knife (LGK) was used for radiosurgical hypophysectomy.
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