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Unravelling Secondary Brain Injury: Insights from a Human-Sized Porcine Model of Acute Subdural Haematoma.
Cells
December 2024
Institute of Anaesthesiologic Pathophysiology and Process Development, University Hospital Ulm, Helmholtzstrasse 8/1, 89081 Ulm, Germany.
Article Synopsis
- Traumatic brain injury (TBI) is a leading cause of death, complicating the development of effective therapies due to the unique nature of each injury.
- Clinical questions regarding the benefits of measuring intracranial pressure, cerebral perfusion pressure, and surgical interventions remain largely unanswered.
- This study focused on acute subdural hematoma in a porcine model to better understand secondary brain injury and the effects of different injury patterns on outcomes, highlighting the need for comprehensive models to improve TBI treatment translation.
Therapeutic hypothermia in preterm infants under 36 weeks: Case series on outcomes and brain MRI findings.
Eur J Pediatr
January 2025
Neonatology Department. Hospital Sant Joan de Déu, Center for Maternal Fetal and Neonatal Medicine. Neonatal Brain Group, Universitat de Barcelona. Hospital Clínic, Universitat de Barcelona. BCNatal - Barcelona, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
Purpose: Perinatal hypoxic-ischemic encephalopathy (HIE) is a significant cause of neonatal brain injury. Therapeutic hypothermia (TH) is the standard treatment for term neonates, but its safety and efficacy in neonates < 36 weeks gestational age (GA) remains unclear. This case series aimed to evaluate the outcomes of preterm infants with HIE treated with TH.
View Article and Find Full Text PDFGlioneuronal heterotopia in the right middle cranial fossa.
Free Neuropathol
January 2024
Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, USA.
Logistic organ dysfunction system as an early risk stratification tool after aneurysmal subarachnoid hemorrhage.
Sci Rep
November 2024
Department of Neurosurgery, University Medical Center Göttingen, Göttingen, Germany.
Aneurysmal subarachnoid hemorrhage (aSAH) not only causes neurological deficits but also influences extracerebral organ functions. The Logistic Organ Dysfunction System (LODS) reliably captures organ dysfunctions and predicts mortality of critically ill patients. This study investigated LODS in the setting of aSAH as a surrogate marker for early brain injury (EBI).
View Article and Find Full Text PDFPrognostic role of serum copeptin levels in adults with graded traumatic brain injury.
Ir J Med Sci
October 2024
Department of Emergency Medicine, University of Health Sciences, Haseki Training and Research Hospital, Ugur Mumcu, Atatürk Street 54, 34265, Sultangazi, Istanbul, Turkey.
Article Synopsis
- * Results show that patients with moderate to severe TBI have significantly higher copeptin levels than those with mild injuries, with a specific cutoff value indicating more severe trauma.
- * Elevated copeptin levels also correlate with abnormal CT scans and higher mortality rates within 28 days, suggesting that it can be a useful biomarker in managing head trauma patients.
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