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Progress in targeted therapy for ankylosing spondylitis: A review.
Medicine (Baltimore)
November 2024
Department of Anesthesiology, Jilin Province FAW General Hospital, Changchun City, Jilin Province, China.
Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by axial osteoarticular inflammation and tendon enthesitis with unclear pathogenesis. Nonsteroidal anti-inflammatory drugs and antirheumatic drugs used in the traditional treatment of AS have some problems such as drug intolerance and inadequate treatment response. Since the introduction of biological agents in the treatment of AS, they have completely changed the treatment concept of AS, and because of their safety and good tolerance, they have become the main choice for clinical AS patients.
View Article and Find Full Text PDFCase report: osteo-articular infection in a patient with Chronic Granulomatous Disease.
Med Mycol Case Rep
December 2024
Université Paris Cité, Faculté de Médecine, APHP, Hôpital Necker Enfants malades, Service de Maladies Infectieuses et Tropicales, 149 rue de Sèvres, 75015, Paris, France.
is a recently reported yeast causing rare cases of fungemia. This species presents high minimum inhibitory concentrations (MICs) to fluconazole and echinocandins. We report an atypical metacarpophalangeal osteo-articular infection in a patient with Chronic Granulomatous Disease.
View Article and Find Full Text PDFMusculoskeletal involvement in systemic sclerosis.
Reumatologia
August 2024
Department of Rheumatology and Systemic Connective Tissue Diseases, Independent Public Hospital No. 4 in Lublin, Poland.
Article Synopsis
- Systemic sclerosis (SSc) is a serious connective tissue disease affecting multiple organs, including the lungs, heart, and musculoskeletal system, with musculoskeletal involvement occurring in 40-90% of patients.
- Common symptoms include joint pain, arthritis, and issues such as tendon rupture and calcinosis, which negatively impact the quality of life and can lead to disabilities.
- Understanding the causes of these musculoskeletal issues could help develop new treatments, improving patient outcomes and reducing complications.
Measles-Clinical and Biological Manifestations in Adult Patients, Including a Focus on the Hepatic Involvement: Results from a Single-Center Observational Cohort Study from Romania.
J Clin Med
September 2024
Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 050474 Bucharest, Romania.
: Hepatic involvement in measles, particularly among adolescents and adults, has been recognized since 1960. This involvement typically manifests during the eruptive phase of the disease and is primarily characterized by hepatocellular dysfunction, with jaundice being a less common occurrence. Studies have reported hepatic involvement in 80-86% of measles cases among young adults associated with severe forms of the disease with intra-infectious hepatitis.
View Article and Find Full Text PDFPredictive Factors for Total Knee Arthroplasty: An Observational Study.
Cureus
August 2024
Orthopaedics and Traumatology, Bucharest Emergency University Hospital, Bucharest, ROU.
Article Synopsis
- Knee osteoarthritis (KOA) is the most common type of osteoarthritis, diagnosed through clinical assessment and knee X-rays, and is influenced by various prognostic and risk factors like age, BMI, and physical activity.
- A study at the University Emergency Hospital in Bucharest included 70 KOA patients, examining those needing surgical vs. non-surgical treatments based on specific criteria, focusing on patients over 45 with knee pain and radiographic evidence of KOA.
- Results showed that patients requiring total knee arthroplasty (TKA) were significantly older than those needing other treatments, with a notable difference in age and a higher prevalence of KOA in women.
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