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Are there any session-to-session changes in ventilation during a weekly hemodialysis cycle?
Int J Artif Organs
January 2025
Nalecz Institute of Biocybernetics and Biomedical Engineering Polish Academy of Sciences, Warsaw, Poland.
Significant changes in pre-dialytic partial pressure of CO (pCO) during a week-long cycle of hemodialysis (HD) can be an effect of the intermittent supplementation of bicarbonate to correct chronic acidosis in patients. Mathematical modeling efforts carried out using the same parameters before each HD session might fail to produce accurate predictions of pCO and plasma bicarbonate concentration (C) because of this variability. A numerical model describing acid-base equilibrium changes during HD was applied to predict pCO, pH, and C in 24 chronic HD patients, using both fixed parameters for the whole week and estimating a new value of minute ventilation (V) and net acid generation rate (G) for each interdialytic interval.
View Article and Find Full Text PDFHow To Correct Erroneous Symmetry-Breaking in Coarse-Grained Constant-pH Simulations.
J Chem Theory Comput
January 2025
Institute for Computational Physics, University of Stuttgart, Allmandring 3, Stuttgart 70569, Germany.
The constant-pH Monte Carlo method is a popular algorithm to study acid-base equilibria in coarse-grained simulations of charge regulating soft matter systems including weak polyelectrolytes and proteins. However, the method suffers from systematic errors in simulations with explicit ions, which lead to a symmetry-breaking between chemically equivalent implementations of the acid-base equilibrium. Here, we show that this artifact of the algorithm can be corrected a-posteriori by simply shifting the pH-scale.
View Article and Find Full Text PDFHeterogeneous Frustrated Lewis Pair Catalysts: Rational Structure Design and Mechanistic Elucidation Based on Intrinsic Properties of Supports.
Acc Chem Res
January 2025
The Wolfson Catalysis Centre, Department of Chemistry, University of Oxford, Oxford OX1 3QR, U.K.
ConspectusThe discovery of reversible hydrogenation using metal-free phosphoborate species in 2006 marked the official advent of frustrated Lewis pair (FLP) chemistry. This breakthrough revolutionized homogeneous catalysis approaches and paved the way for innovative catalytic strategies. The unique reactivity of FLPs is attributed to the Lewis base (LB) and Lewis acid (LA) sites either in spatial separation or in equilibrium, which actively react with molecules.
View Article and Find Full Text PDFAssociation of elevated albumin-corrected anion gap with all-cause mortality risk in atrial fibrillation: a retrospective study.
BMC Cardiovasc Disord
January 2025
Department of Cardiovascular Diseases, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui, China.
Background: Compared to the conventional anion gap, the albumin-corrected anion gap (ACAG) offers a more precise measure of acid-base imbalance, providing superior prognostic insight. However, the prognostic relevance of ACAG in individuals of atrial fibrillation (AF) remains insufficiently explored. This research seeks to evaluate the correlation between ACAG levels and mortality risk in individuals with AF.
View Article and Find Full Text PDFAssociation between albumin corrected anion gap and in-hospital mortality in critically ill patients with chronic obstructive pulmonary disease.
Ther Adv Respir Dis
January 2025
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong, Chongqing 400016, China.
Background: The relationship between albumin-corrected anion gap (ACAG) and in-hospital mortality in critically ill patients with COPD remains unclear.
Objective: This study investigated the association between ACAG levels and the risk of in-hospital mortality in critically ill patients with COPD.
Design: A retrospective cohort study.
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