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Lipase maturation factor 1 is an endoplasmic reticulum-resident transmembrane protein, which acts as a critical chaperone necessary for the folding, dimerisation, and secretion of lipases. In this review, we summarise data about the recently revealed role of lipase maturation factor 1 in endoplasmic reticulum redox homeostasis, its novel interaction partners among oxidoreductases and lectin chaperones, and the identification of fibronectin and the low-density lipoprotein receptor as novel non-lipase client proteins of lipase maturation factor 1. Additionally, the role of lipase maturation factor 1-derived circular RNA in atherosclerosis progression via the miR-125a-3p/vascular endothelial growth factor A\Fibroblast Growth Factor 1 axis is discussed.
View Article and Find Full Text PDFSphingomyelins of Local Fat Depots and Blood Serum as Promising Biomarkers of Cardiovascular Diseases.
Sovrem Tekhnologii Med
October 2024
Associate Professor, Professor of the Russian Academy of Sciences, Head of the Laboratory for Homeostasis Research, Department of Experimental Medicine; Research Institute for Complex Issues of Cardiovascular Diseases, 6 Academician L.S. Barbarash Blvd, Kemerovo, 650002, Russia; Head of the Department of Medical Biochemistry; Kemerovo State Medical University, 22A Voroshilov St., Kemerovo, 650056, Russia.
Unlabelled: Assessment of the blood lipid spectrum does not always properly reflect local dysfunctional changes in the adipose tissue and prevents identification of all patients at high risk of cardiovascular diseases (CVD). Monitoring of changes in sphingomyelin levels allows to assess and anticipate the development and/or severity of these diseases, as well as to make sphingomyelins new therapeutic targets. was to evaluate the sphingomyelin spectrum of local fat depots and blood serum in connection with clinical and instrumental indicators in patients with coronary artery disease (CAD) and patients with degenerative acquired valvular heart disease (AVHD).
View Article and Find Full Text PDFThe Influence of Personality Type D and Coping Strategies on Cognitive Functioning in Students.
Behav Sci (Basel)
May 2024
Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Blvd. Named Academician L.S. Barbarasha, 6, Kemerovo 650002, Russia.
Introduction: Academic and emotional challenges faced by medical students can affect their psychological well-being and health. Personal characteristics may also predispose one to the manifestation of distress reactions. Individuals with type D personality have an increased tendency to develop depressive reactions and somatic diseases, including the presence of cognitive dysfunction.
View Article and Find Full Text PDFProspective multicenter online testing of the carotid endarterectomy risk stratification calculator carotidscore.ru.
Indian J Thorac Cardiovasc Surg
November 2023
First Moscow State Medical University Named After Sechenov, Moscow, Russian Federation.
Aim: To evaluate the incidence of complications, including fatal outcomes, ischemic strokes, and transient ischemic attacks, associated with carotid endarterectomy (CEA) in patients categorized as low-, medium-, and high-risk based on their CarotidSCORE (carotidscore.ru).
Material And Methods: This prospective, multicenter study was conducted from January 1, 2022, to December 20, 2022, and enrolled 5,496 patients with stenosis of the internal carotid artery (ICA), who were categorized into four groups according to their risk level.
Highly efficient near-infrared solid solution phosphors with excellent thermal stability and tunable spectra for pc-LED light sources toward NIR spectroscopy applications.
Phys Chem Chem Phys
October 2023
College of Materials Science and Engineering, Chongqing University of Arts and Sciences, Chongqing, 402160, China.
Near-infrared (NIR) luminescent materials have attracted wide research interest due to their unique photophysical properties for designing NIR light-emitting diodes (NIR LEDs). Here, a series of Cr-activated NIR-emitting solid solution phosphors, GdLu(AlSc)(BO):0.01Cr (GLASB:Cr) ( = 0 to 0.
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