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Preparation and Properties of Crosslinked Quaternized Chitosan-Based Hydrogel Films Ionically Bonded with Acetylsalicylic Acid for Biomedical Materials.
Mar Drugs
September 2024
Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
The aim of the current study is to develop chitosan-based biomaterials which can sustainably release acetylsalicylic acid while presenting significant biological activity. Herein, an innovative ionic bonding strategy between hydroxypropyl trimethyl ammonium chloride chitosan (HACC) and acetylsalicylic acid (AA) was proposed, skillfully utilizing the electrostatic attraction of the ionic bond to achieve the controlled release of drugs. Based on this point, six crosslinked -[(2-hydroxy-3-trimethylammonium)propyl]chitosan acetylsalicylic acid salt (CHACAA) hydrogel films with varying acetylsalicylic acid contents were prepared by a crosslinking reaction.
View Article and Find Full Text PDFIn-line NIR coupled with machine learning to predict mechanical properties and dissolution profile of PLA-Aspirin.
Funct Compos Mater
October 2024
Centre for Mathematical Modelling and Intelligent Systems for Health and Environment (MISHE), Atlantic Technological University, ATU Sligo, Ash Lane, Co. Sligo F91 YW50 Ireland.
Unlabelled: In the production of polymeric drug delivery devices, dissolution profile and mechanical properties of the drug loaded polymeric matrix are considered important Critical Quality Attributes (CQA) for quality assurance. However, currently the industry relies on offline testing methods which are destructive, slow, labour intensive, and costly. In this work, a real-time method for predicting these CQAs in a Hot Melt Extrusion (HME) process is explored using in-line NIR and temperature sensors together with Machine Learning (ML) algorithms.
View Article and Find Full Text PDFAspirin-Loaded Anti-Inflammatory ZnO-SiO Aerogel Scaffolds for Bone Regeneration.
ACS Appl Mater Interfaces
April 2024
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, P R China.
Article Synopsis
- The aging population is facing increased risks from bone defects, making it necessary to find effective treatments, with aerogel materials showing promise due to their ECM-like properties.
- Research developed flexible ZnO-SiO nanofiber scaffolds that, when combined with chitosan and aspirin, demonstrated improved biocompatibility, mechanical strength, and the ability to boost bone growth and vascularization.
- In mouse models, the new scaffolds significantly outperformed controls in promoting new bone formation, likely due to the release of beneficial components that enhance the body's healing response and reduce inflammation.
Formulation of aspirin nanoparticles using solvent evaporation method and in vivo evaluation of its antithrombotic effect.
Pak J Pharm Sci
September 2023
Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, Cyprus.
Nanotechnology offers several advantages in the treatment of chronic diseases through site-specific and target-oriented drug delivery. The purpose of this study was to formulate aspirin nanoparticles using the solvent evaporation method and evaluate the physicochemical properties of nanoparticles using X-ray diffraction (XRD), scanning electron microscope (SEM), Fourier Transform Infrared Spectroscopy (FTIR) and zeta sizer. In vitro dissolution studies, release kinetics, antioxidant and in vivo antithrombotic studies were also done.
View Article and Find Full Text PDFPharmacokinetic Study of Enteric-Coated Sustained-Release Aspirin Tablets in Healthy Chinese Participants.
Drug Des Devel Ther
September 2023
Clinical Trial Center, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Beijing, People's Republic of China.
Purpose: To study and compare the pharmacokinetic characteristics of enteric-coated sustained-release (EcSr) aspirin tablets with enteric-coated (Ec) aspirin tablets (Bayer S.p.A) in healthy Chinese participants.
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