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Effect of β-catenin on hypoxia induced epithelial mesenchymal transition in HK-2 cells by regulating Brachyury.
Biochem Biophys Rep
March 2025
Department of Nephrology, Pu'er People's Hospital, Pu'er, Yunnan, China.
Background: Chronic kidney disease (CKD) has become a worldwide health problem and the incidence rate and mortality of CKD have been rising. Renal fibrosis (RF) is the final common pathological feature of almost all kinds of CKD and Epithelial-mesenchymal transition (EMT) is the predominant stage of RF. β-catenin is a key component of the Wnt signaling pathway, which has been fully proven to promote EMT.
View Article and Find Full Text PDFUnveiling with Density Functional Theory the Optical Property Variations of Three Kinds of Graphene for Acetaminophen Sensor Design.
ACS Omega
January 2025
Instituto de Física, Universidad Nacional Autónoma de México, código postal 04510, Mexico City 01000, Mexico.
Understanding the interactions between molecules and sensing elements is crucial to improving sensors. We present one step toward getting closer to the breach between theory and empirical sensor development. Through density functional theory (DFT) calculations, we explored the changes in some optical properties of pristine graphene (G), graphene oxide (GO), and reduced graphene oxide (rGO) interacting with one molecule of acetaminophen (APAP).
View Article and Find Full Text PDFCharacterization of Volatile Compounds in Mozzarella Cheeses Made from Bovine and Buffalo Milk by SPME-GC×GC-O-TOFMS, SPME-Arrow-GC-MS and GC-IMS.
J Dairy Sci
January 2025
Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, Beijing 100048, China. Electronic address:
High moisture Mozzarella cheese is particularly popular because of its freshness and milky flavor, however the difference in aroma compound composition between high moisture Mozzarella cheese made from bovine (BOC) and buffalo milk (BUC) remains unclear. Herein, the volatile compounds of 2 kinds of Mozzarella cheese were qualitatively and quantitatively analyzed by SPME-GC × GC-O-TOFMS, SPME-Arrow-GC-MS and GC-IMS for the first time. A total of 139 volatile compounds were identified (69 aroma active compounds were sniffed), of which 106 were identified in BOC and 96 in BUC.
View Article and Find Full Text PDFHuman urinary occurrence of thiourea vulcanization accelerators and their human exposure.
Environ Pollut
January 2025
Taizhou Central Hospital (Taizhou University Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, PR China. Electronic address:
Thiourea vulcanization accelerators (TVAs) have been detected in various household dust samples, indicating their widespread human exposure. Until now, the occurrence of TVAs in human urine, a suitable matrix for assessing human exposure, has remained unknown. The present study comprehensively examined eight kinds of TVAs in urine samples (n = 277) from participants living in Taizhou, China.
View Article and Find Full Text PDFRandom lasers (RLs) with a simple structure and low-cost properties have been recognized as an ideal analytical platform and are still challenging for liquid detecting, remaining beset for low sensitivity, complicated operation, and large analyte consumption. Here, inspired by a microfluidic sensor, a microtubule structured random laser for multifunctional sensing is demonstrated. The random laser is achieved resorting to a curly PMMA film with gain and scatterers embedded in it.
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