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Elucidating the impact of S-adenosylmethionine and histamine binding on N-methyltransferase conformational dynamics: Insights from an in silico study.
J Mol Graph Model
January 2025
Tianjin Institute of Industrial Biotechnology of Chinese Academy of Sciences, National Technology Innovation Center of Synthetic Biology, Tianjin, 300308, China. Electronic address:
S-adenosylmethionine (SAM)-dependent histamine N-methyltransferase (HNMT) is a crucial enzyme involved in histamine methylation, playing an important role in the epigenetic modification of biology. It entails the addition of methyl groups to histamine molecules, thereby regulating gene expression, cellular signal transduction, and other biological processes. Therefore, gaining a profound understanding of the detailed mechanism underlying HNMT-mediated methylation reactions is instrumental in elucidating the role of histamine methylation in biology.
View Article and Find Full Text PDFIntegrating Machine Learning and Pharmacophore Features for Enhanced Prediction of H1 Receptor Blockers.
Med Chem
January 2025
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Introduction: Histamine Type I Receptor Antagonists (H1 blockers) are widely used to mitigate histamine-induced inflammation, particularly in allergic reactions. Histamine, a biogenic amine found in endothelial cells, vascular smooth muscle, bronchial smooth muscle, and the hypothalamus, is a key player in these responses. H1 blockers are essential in cough syrups and flu medications and are divided into two generations: first-generation H1 blockers, which are sedating and have numerous side effects, and second-generation blockers, which are non-sedating and generally less toxic but may still exhibit cross-reactivity with other receptors.
View Article and Find Full Text PDFUltrasound-assisted cold plasma treatment reduces resistance to in vitro digestion of tropomyosin and Allergenicity of tropomyosin digestion products.
Food Chem
January 2025
School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China; Academy of Contemporary Food Engineering, South China University of Technology, Guangzhou Higher Education Mega Centre, Guangzhou 510006, China; Engineering and Technological Research Centre of Guangdong Province on Intelligent Sensing and Process Control of Cold Chain Foods, & Guangdong Province Engineering Laboratory for Intelligent Cold Chain Logistics Equipment for Agricultural Products, Guangzhou Higher Education Mega Centre, Guangzhou 510006, China. Electronic address:
Tropomyosin (TM), the primary allergen in crustacean aquatic products, has excellent thermal and digestive stability. In this work, the changes in digestive resistance of TM and allergenicity of TM digestion products induced by ultrasound-assisted cold plasma (UCP) treatment were investigated. The stability of TM to simulated digestion were reduced, especially the simulated intestinal fluid (SIF) digestive resistance.
View Article and Find Full Text PDFRed Currant ( L.) Fruit Waste Extract and Juice as Potential Spasmolytic Agents.
Plants (Basel)
January 2025
Department of Pharmacy, Faculty of Medicine, University of Niš, Dr. Zoran Djindjić Ave 81, 18000 Niš, Serbia.
Red currant ( L.) berries are rich in bioactive compounds and exhibit nutritive and protective features. This research examined the content of secondary metabolites of the red currant variety Redpoll lyophilized juice and waste extract and their antioxidative and spasmolytic effects.
View Article and Find Full Text PDFYeokwisan: Standardised Herbal Formula Enhancing Gastric Mucosal Protection Against Gastric Ulcers in Mice, a Preclinical Study.
Pharmaceuticals (Basel)
January 2025
KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
: Yeokwisan (YWS) is a standardised herbal formula for relieving functional dyspepsia symptoms. : We explored the therapeutic value of YWS and its potential effects on gastritis. Its inhibitory effect on gastric mucosal damage and anti-inflammatory activity in animal models of alcohol- and restraint stress-induced gastritis were also examined.
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