After incubation of reticulocytes with radioactive amino acid, the specific activity of the beta-chain of globin from the blood of patients with thalassemia was consistently lower than that of the alpha-chain. In subjects without this disorder, the specific activity of the beta-chain was always equal to or higher than that of the alpha-chain.
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| http://dx.doi.org/10.1126/science.146.3643.530 | DOI Listing |
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