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Cushing's Myopathy in Dogs: Prevalence, Clinical Abnormalities, and Response to Treatment.
Animals (Basel)
October 2024
Specialists in Companion Animal Neurology, Naples, FL 34135, USA.
A distinct myotonia is a muscle disorder that may occur secondary to excess corticosteroids (hyperadrenocorticism, HAC, or Cushing's disease) and is associated with electrodiagnostic abnormalities on electromyography (EMG). Clinically these disorders cause muscle stiffness, weakness, atrophy, and/or contractures, which can severely limit the quality of life of those affected. To date, there are very few published data regarding the onset, development, and treatment of hyperadrenocorticism-associated myotonia/pseudomyotonia.
View Article and Find Full Text PDFA case of severe Covid-19 infection as the first manifestation of Cushing's disease.
Endocrinol Diabetes Metab Case Rep
October 2024
Department of Endocrinology, Hospital Egas Moniz, CHLO, Lisbon, Portugal.
Article Synopsis
- * A 20-year-old male with undiagnosed CD experienced critical health issues during a severe COVID-19 infection, requiring intensive care and showcasing classic signs of hypercortisolism, leading to further diagnostic testing.
- * After surgical intervention for CD, the patient showed significant health improvements, including better body composition and mood, highlighting the importance of early recognition and timely treatment of hypercortisolism to prevent serious complications.
Circulating miR-28-5p is overexpressed in patients with sarcopenia despite long-term remission of Cushing's syndrome: a pilot study.
Front Endocrinol (Lausanne)
August 2024
CIBERER Unit 747, Instituto de Salud Carlos III, Madrid, Spain.
Article Synopsis
- * A study involving 36 women in remission from CS identified specific circulating microRNAs (miRNAs)—specifically miR-28-5p, miR-495-3p, and miR-654-5p—that could serve as potential biomarkers for the condition.
- * Among these, miR-28-5p showed promise as a non-invasive biomarker for identifying CS patients with sarcopenia, demonstrating an 86% sensitivity and a specificity of 69% at a determined cut-off value.
Diagnostic dilemma in Cushing's syndrome: discrepancy between patient-reported and physician-assessed manifestations.
Endocrine
October 2024
Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, Kobe, Hyogo, 650-0017, Japan.
Article Synopsis
- The study investigates the discrepancies between patient-reported and physician-assessed symptoms of Cushing's syndrome (CS), highlighting challenges in early diagnosis and treatment.
- It includes a retrospective analysis of 52 patients with CS to compare their reported manifestations with those identified by physicians, focusing on typical and nonspecific symptoms.
- Findings reveal that while patients correlated well with physicians on nonspecific symptoms, they reported fewer typical symptoms, which are critical for diagnosis, indicating that patients may not recognize these typical features as problems.
Evaluation of muscle mass and intramuscular fatty infiltration in dogs with hypercortisolism and their association with prognosis.
J Vet Intern Med
May 2024
Joint Department of Veterinary Medicine, The United Graduate School of Veterinary Science, Gifu University, Gifu, Japan.
Background: Muscle atrophy and intramuscular fatty infiltration, as well as their association with prognosis, have not been quantified in dogs with spontaneous hypercortisolism (HC).
Objective: To quantitatively evaluate muscle atrophy and IM fatty infiltration in dogs with HC and determine their prognostic impact.
Animals: Fifty-three dogs with HC and 66 control dogs without HC.
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