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Impact of Lysine to Methionine Ratios on Antioxidant Capacity and Immune Function in the Rumen of Tibetan Sheep: An RNA-Seq Analysis.
Vet Med Sci
January 2025
College of Agriculture and Animal Husbandry, Qinghai University, Xining, People's Republic of China.
With global protein prices on the rise, lowering protein levels in animal feed, together with balancing diet composition and reducing nitrogen emissions, can both reduce the environmental impact of agriculture and save on feed costs. However, the formulation of an ideal amino acid (AA) composition is crucial for better protein utilization by livestock. This study aimed to investigate the effects of different lysine to methionine ratios on the antioxidant capacity and immune function of the rumen in Tibetan sheep.
View Article and Find Full Text PDFIntegrated data from intravital imaging and HPLC-MS/MS analysis reveal large interspecies differences in AFB metabolism in mice and rats.
Arch Toxicol
April 2024
Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystraße 67, 44139, Dortmund, Germany.
Large interspecies differences between rats and mice concerning the hepatotoxicity and carcinogenicity of aflatoxin B (AFB) are known, with mice being more resistant. However, a comprehensive interspecies comparison including subcellular liver tissue compartments has not yet been performed. In this study, we performed spatio-temporal intravital analysis of AFB kinetics in the livers of anesthetized mice and rats.
View Article and Find Full Text PDFRole of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification.
Neuropsychopharmacology
July 2024
Department of Psychology, University of Toronto Mississauga, Mississauga, ON, L5L 1C6, Canada.
Creating long-lasting memories requires learning-induced changes in gene expression, which are impacted by epigenetic modifications of DNA and associated histone proteins. Post-translational modifications (PTMs) of histones are key regulators of transcription, with different PTMs producing unique effects on gene activity and behavior. Although recent studies implicate histone variants as novel regulators of memory, effects of PTMs on the function of histone variants are rarely considered.
View Article and Find Full Text PDFSolid-Phase Synthesis of Caged Luminescent Peptides via Side Chain Anchoring.
Bioconjug Chem
December 2023
Institute for Molecules and Materials, Radboud University, Nijmegen 6525 AJ, The Netherlands.
The synthesis of caged luminescent peptide substrates remains challenging, especially when libraries of the substrates are required. Most currently available synthetic methods rely on a solution-phase approach, which is less suited for parallel synthesis purposes. We herein present a solid-phase peptide synthesis (SPPS) method for the synthesis of caged aminoluciferin peptides via side chain anchoring of the P residue.
View Article and Find Full Text PDFPolycystic ovary syndrome (PCOS) is a prevalent reproductive endocrine disorder, with metabolic abnormalities and ovulation disorders. The post-translational modifications (PTMs) are functionally relevant and strengthen the link between metabolism and cellular functions. Lysine crotonylation is a newly identified PTM, the function of which in PCOS has not yet been reported.
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