The involvement of retroviruses in the etiopathogenesis of autoimmunity is discussed. Recently antibodies against p24 of HIV-1 were described in patients from Texas with SLE. Therefore we investigated the presence of these antibodies in our SLE collective (German caucasians and blacks from Michigan) employing ELISA and Western blot. No anti-p24 reactivity was observed in our SLE patients in Western blots, suggesting that there may be ethnological or regional differences between our patients those from Texas.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1089/vim.1992.5.229 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Early and Sustained Response to Benralizumab in Severe, Eosinophilic Asthma: A Real-World Observational Study.
J Asthma Allergy
December 2024
Pulmonology Clinic, Cantonal Hospital Graubünden, Chur, Switzerland.
Purpose: Although studies have evaluated benralizumab, a monoclonal IL-5 receptor α antibody in severe eosinophilic asthma (SEA), in real-world settings, additional evidence is needed to further characterize its effectiveness in specific patient populations. Our study aimed to evaluate asthma control over 56 weeks in patients treated with benralizumab in Swiss real-world settings.
Patients And Methods: Conducted across 13 centres, this prospective, observational, non-interventional study involved 73 adults with physician confirmed SEA.
Fourth-Generation HIV Rapid Tests: Enhanced Sensitivity and Reduced Diagnostic Window for HIV-1 Primary Infection Screening.
J Med Virol
November 2024
Laboratoire de Virologie, INSERM, Institut Pierre Louis d' Epidémiologie et de Santé Publique, AP-HP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Sorbonne Université, Paris, France.
Article Synopsis
- Most HIV rapid tests primarily detect antibodies, which makes them less effective in identifying early HIV infections.
- The Determine test, which includes p24-antigen detection, shows better overall sensitivity compared to the One-Step test, particularly during the early stages of infection.
- Using tests that detect p24-antigen can reduce the diagnostic window significantly, from around 3 months to about 1 month, but caution is advised when testing in the first month after infection.
Molecular sandwich-based DNAzyme catalytic reaction towards transducing efficient nanopore electrical detection of antigen proteins.
Faraday Discuss
October 2024
Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences & Chongqing School, The University of Chinese Academy of Sciences, Chongqing, 400714, China.
Despite significant advances in nanopore nucleic acid sequencing and sensing, protein detection remains challenging due to the inherent complexity of protein molecular properties (, net charges, polarity, molecular conformation & dimension) and sophisticated environmental parameters (, biofluids), resulting in unsatisfactory electrical signal resolution for protein detection such as poor accessibility, selectivity and sensitivity. The selection of an appropriate electroanalytical approach is strongly desired which should be capable of offering easily detectable and readable signals regarding proteins particularly depending on the practical application. Herein, a molecular sandwich-based cooperative DNAzyme catalytic reaction nanopore detecting approach was designed.
View Article and Find Full Text PDFImprovement of blood transfusion safety using the chemiluminescence technique for viral marker screening of blood donors in sub Saharan Africa.
Hematol Transfus Cell Ther
November 2024
National Centre of Blood Transfusion (NCBT/CNTS), Dakar, Senegal; Service of Haematology; Department of Medicine; Faculty of Medicine, Pharmacy and Odonto-Stomatology (FMPOS), University Cheikh Anta Diop of Dakar (UCAD), Dakar, Senegal.
Introduction: Sub-Saharan Africa struggles continuously with insufficient resources and inadequate infrastructure that hinder the establishment of a safer blood supply despite improvements in transfusion safety over recent decades. This study aimed to evaluate the impact of the chemiluminescence technique in combination with immunoenzymatic and immunochromatographic tests for viral marker screening of hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV) in donated blood in a country of sub-Saharan Africa.
Method: This study was conducted in a population of 113,406 blood donors at the National Centre of Blood Transfusion in Senegal.
Effects on molecular interactions of hollow gold nanoparticles and antibody for sensitizing P24 antigen determination.
RSC Adv
September 2024
Department of Infectious Disease, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine Nanjing 210003 China +86-13851507368.
In recent years, with the rapid development of point-of-care testing, the application of lateral flow immunochromatography assay (LFIA) has become increasingly widespread. The key to the success of these detection technologies is the effective binding with diagnostic materials and detection antibody proteins. Although many researchers have tried to optimize antibody binding, a universally accepted strategy that can provide maximum performance has not been determined.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!