Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models.
Neuropharmacology
June 2006
Shanghai Celstar Institute of Biotechnology, 1 Ju Li Road, Shanghai 201203, People's Republic of China.
The protopine isolated from a Chinese herb Dactylicapnos scandens Hutch was identified as an inhibitor of both serotonin transporter and noradrenaline transporter in vitro assays. 5-hydroxy-DL-tryptophan(5-HTP)-induced head twitch response (HTR) and tail suspension test were adopted to study whether protopine has anti-depression effect in mice using reference antidepressant fluoxetine and desipramine as positive controls. In HTR test, protopine at doses of 5, 10, 20 mg/kg dose dependently increase the number of 5-HTP-induced HTR.
View Article and Find Full Text PDFBehavioral characteristics of olanzapine: an atypical neuroleptic.
Acta Pharmacol Sin
April 2000
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China.
Aim: To assess the atypical neuroleptic properties of a novel antipsychotic agent, olanzapine (Ola).
Methods: The action of Ola on apomorpine (Apo)-induced climbing behavior, 5-hydroxy-dl-tryptophan (5-HTP)-induced head twitch response, oxotremorine-induced tremor, and the conditioned avoidance behavior in mice were observed. The catalepsy of mice induced by Ola was also investigated.
Effect of serotonin on the chemiluminescence response of rat peripheral blood leucocytes.
Int J Immunopharmacol
October 1995
Laboratoire de Pharmacologie et Toxicologie Médicale, et INSERM U80, Lyon, France.
Serotonin (5-HT) has been shown to exert various immunomodulatory effects. In this study, the effects of 5-HT, 5-hydroxy-DL-tryptophan (5-HTP) and DL-p-chlorophenylalanine (PCPA) on the chemiluminescence (CL) responses of rat peripheral blood leucocytes (PBL) activated by phorbol myristate acetate (PMA), opsonized zymosan or latex beads were assessed. The CL responses were measured following in vitro treatment with 0.
View Article and Find Full Text PDFPlateau potentials in alpha-motoneurones induced by intravenous injection of L-dopa and clonidine in the spinal cat.
J Physiol
November 1988
Department of Neurophysiology, Panum Institute, University of Copenhagen, Denmark.
1. Intracellular recordings were made from lumbar alpha-motoneurones in unanaesthetized decerebrate acute spinal cats. The response of motoneurones to direct current pulse injection or synaptic excitation was investigated following intravenous injection of L-beta-3,4-dihydroxyphenylalanine (L-DOPA, 20-120 mg/kg) alone, nialamide (10-50 mg/kg) and L-DOPA or clonidine (0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!