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Self-assembly of malto-oligosaccharide-block-solanesol in aqueous solutions: Investigating morphology and sugar-based physiological compatibility.
Carbohydr Polym
March 2025
Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan. Electronic address:
Starch-derived hydrophilic malto-oligosaccharides (Glc, where n = 1-7) conjugated to hydrophobic solanesol through click chemistry, i.e., Glc-b-Sol copolymers, have demonstrated significant promise in developing fully natural block co-oligomers for solid-state nanopatterning applications.
View Article and Find Full Text PDFNAT10 promotes pyroptosis and pancreatic injury of severe acute pancreatitis through ac4C modification of NLRP3.
Shock
January 2025
Senior Department of Hepato-Pancreato-Biliary Surgery, The First Medical Center of PLA General Hospital, Beijing, China.
Severe acute pancreatitis (SAP) is a highly morbid acute digestive disorder linked to pyroptosis. N-acetyltransferase 10 (NAT10) facilitates the production of N4-acetylcytidine (ac4C) modifications in mRNA, thereby contributing to the progression of various diseases. However, the specific role of NAT10 in SAP remains to be elucidated.
View Article and Find Full Text PDFAssessment of Garbage Enzyme as a Bioremediation Method for the Wastewater Treatment.
Biotechnol Appl Biochem
January 2025
Department of Civil Engineering, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India.
This study evaluates the efficacy of garbage enzyme (GE) in bioremediation to reduce pollutants in sewage drains that discharge into the natural streams and rivers. Garbage enzyme is prepared with help of brown sugar, fruit, vegetable wastes, and water in the proportion 1:3:10 (by weight), which is then applied to the samples collected from various drainage sites in Jaunpur district, Uttar Pradesh, India. Different concentrations of GE (ranging from 0% to 20%) are mixed with sewage to assess pollution reduction.
View Article and Find Full Text PDFNext-Generation Carbazole-Linked 1,2,4-Triazole-Thione Derivatives: Strategic Design, Synthesis, Molecular Docking, and Evaluation of Antidiabetic Potential.
ACS Omega
January 2025
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, 00433 Nablus, Palestine.
Currently, available therapies for diabetes cannot achieve normal sugar values in a high percentage of treated patients. This work synthesized a series of carbazole-triazole-thione derivatives, and their potential antidiabetic activity was investigated against the key diabetic enzymes α-amylase and glycosidase. Normal human hepatic stellate cells (LX-2) were employed to assess their cytotoxicity and safety, followed by in vivo testing to investigate the hypoglycemic effect of the most promising agent.
View Article and Find Full Text PDFMarine microbes suppressed Vibrio and enhanced biological performance of euryhaline rotifer, Brachionus plicatilis.
Mar Pollut Bull
January 2025
Key Laboratory of Aquaculture Nutrition and Feeds (Ministry of Agriculture and Rural Affairs), Key Laboratory of Mariculture (Ministry of Education), Ocean University of China, Qingdao 266100, China. Electronic address:
The excessive use of antibiotics in mariculture has surpassed permitted levels, leading to their release into surrounding waters and accumulation in cultured organisms, which poses risks to human health and highlighting the urgent need for alternatives to reduce antibiotic use. Therefore, the present study aimed to test four microbes including Debaryomyces hansenii, Ruegeria mobilis, Lactobacillus plantarum and Bacillus subtilis, on lowering Vibrio, promoting population increase and survival of Brachionus plicatilis. The digestive enzymes activity including α-amylase, lipase and protease, microbial retention and biochemical composition of rotifers were analyzed.
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