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Application of the 6-SNP elevated LDL-cholesterol polygenic risk score in individuals with familial hypercholesterolemia phenotype from an Argentine population.
Gac Med Mex
January 2025
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica, Laboratorio de Lípidos y Aterosclerosis, Ciudad Autónoma de Buenos Aires.
Introduction: LDL-cholesterol greater than 190 mg/dL indicates severe hypercholesterolemia (HS) of monogenic and/or polygenic origin. Genetic risk scores (GRS) evaluate potential polygenic causes.
Objective: we applied a GRS of 6-SNP (GRS-6) in HS individuals.
Immunoinformatic based designing of highly immunogenic multi-epitope subunit vaccines to stimulate an adaptive immune response against Junin virus.
Mol Divers
December 2024
Centre for Biotechnology and Microbiology, University of Swat, Swat, Pakistan.
The Junin virus causes Argentine hemorrhagic fever, leading to severe complications such as high fever, malaise, muscle pain, and bleeding disorders, including hemorrhages in the skin and mucous membranes. Neurological issues like confusion, seizures, and coma can also occur. Without prompt and effective treatment, the disease can be fatal, with mortality rates reaching up to 30%.
View Article and Find Full Text PDFUnusual frequency of Trypanosoma cruzi DTU TcI and predominance of hybrid lineages in Triatoma infestans before and after control interventions in the Argentinian Chaco.
Acta Trop
January 2025
Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Laboratorio de Eco-Epidemiología. Intendente Güiraldes 2160, Ciudad Universitaria, C1428EHA, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires. Instituto de Ecología, Genética y Evolución de Buenos Aires (IEGEBA), Ciudad Universitaria, C1428EHA, Buenos Aires, Argentina. Electronic address:
Transmission of Trypanosoma cruzi involves diverse hosts, vectors and parasitic genotypes, in different environments. In recent decades, the distribution of T. cruzi has altered due to urbanization of affected people and vectors.
View Article and Find Full Text PDF[Acute undifferentiated febrile illness among outpatients: differential diagnosis between dengue, zika, Argentine hemorrhagic fever and COVID-19].
Medicina (B Aires)
December 2024
Fundación para la Investigación en Neuro Epidemiología (FINEP), Junín, Buenos Aires, Argentina.
The "acute undifferentiated febrile illness" (AUFI) encompasses a range of diseases characterized by the presence of fever, often prompting consultations in emergency services. During epidemics like COVID-19 or dengue, a surge in consultations occurs, resulting in long wait times for patients. Errors in first diagnosis can result in severe consequences.
View Article and Find Full Text PDF[High blood pressure and associated lifestyles in an urban population in Argentina].
Medicina (B Aires)
December 2024
Escuela de Nutrición, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Introduction: The American Heart Association (AHA/ACC) sets as a goal for blood pressure (BP) control not to exceed values of 130/80 mmHg, both in individuals with and without a diagnosis of hypertension (HT), standards not evaluated so far in the Argentine population. The objective was to determine the prevalence of high BP (HBP) in individuals with and without a diagnosis of HT taking into account the AHA/ACC criteria and to evaluate its association with sociodemographic and lifestyle factors.
Materials And Methods: Cross-sectional populationbased study in 911 persons >18 years of age in Córdoba, Argentina (period 2020-2022).
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