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Measuring XNA polymerase fidelity in a hydrogel particle format.
Nucleic Acids Res
January 2025
Department of Pharmaceutical Sciences, University of California, Irvine, CA 92697-3958, United States.
Growth in the development of engineered polymerases for synthetic biology has led to renewed interest in assays that can measure the fidelity of polymerases that are capable of synthesizing artificial genetic polymers (XNAs). Conventional approaches require purifying the XNA intermediate of a replication cycle (DNA → XNA → DNA) by denaturing polyacrylamide gel electrophoresis, which is a slow, costly, and inefficient process that requires a large-scale transcription reaction and careful extraction of the XNA strand from the gel slice. In an effort to streamline the assay, we developed a purification-free approach in which the XNA transcription and reverse transcription steps occur inside the matrix of a hydrogel-coated magnetic particle.
View Article and Find Full Text PDFSequential and Time-Controlled Sol-Gel Transitions by Mechanical Switching of Molecular Tweezers.
J Am Chem Soc
January 2025
Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, IPCM, 4 place Jussieu, Paris 75005, France.
Controlling the motion of molecular machines to influence higher-order structures is well-established in biological systems but remains a significant challenge for synthetic analogs. Herein, we aim to harness the mechanical switching of switchable molecular tweezers to modulate their self-assembly and produce stimuli-responsive organogels. We report a series of terpy(Pt-salphen) molecular tweezers functionalized with alkyl chains that act as low-molecular-weight gelators (LMWGs) in their open conformation.
View Article and Find Full Text PDFEco-Friendly Fabrication of FeS QD-Chitosan Biopolymer Composites: Green Synthetic Approach.
Biopolymers
March 2025
Department of Chemistry, School of Chemical and Physical Sciences, Lovely Professional University, Phagwara, India.
In this paper, we offer a unique green synthetic approach for producing iron sulfide quantum dots (FeS QD)-chitosan composites using gel chemistry. The technique uses the environmental features of chitosan, a biocompatible and biodegradable polysaccharide, and the excellent electrical properties of FeS QDs. By sustainable chemistry principles, the synthesis process is carried out under gentle settings, using aqueous solutions and avoiding hazardous solvents and strong chemicals.
View Article and Find Full Text PDFGenetic Stability and Inbreeding in a Synthetic Maize Variety Based on a Finite Model.
Plants (Basel)
January 2025
Departamento de Fitotecnia, Instituto de Horticultura, Universidad Autónoma Chapingo, km 38.5 Carretera México-Texcoco, Chapingo 56230, Estado de México, Mexico.
A synthetic variety (SV) of maize may not become stable if the sample size representing each parental line (m) is small. This research aimed to evaluate the effect of m on the inbreeding coefficient (IC) of the SV (FSynL) and on the stability of its genetic constitution. An SV formed by randomly mating l unrelated lines whose inbreeding coefficient is F was considered, and a random sample was taken from the genotypic array of the progeny produced by selfing a parental line A1A2 (GA) This sample was visualized as a set of g groups of four plants whose genotypes are all four of the GA and e represented the number of plants that failed to form a group.
View Article and Find Full Text PDFExploring the potential of Mon-Pu (Glochidion wallichianum) leaf extract as a natural antioxidant for Ligor chicken meat gel: Impact on gelation functionality and oxidative stability.
Poult Sci
January 2025
Food Technology and Innovation Research Center of Excellence, School of Agricultural Technology and Food Industry, Walailak University, Nakhon Si Thammarat 80160, Thailand.
This study evaluated the antioxidant potential of Mon-Pu (Glochidion wallichianum Mull. Arg.) leaf extract (MPLE) as a natural antioxidant in Ligor chicken meat gels.
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