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Sarcoidosis presenting as a suspected metastasis around the optic disc.
BMJ Case Rep
March 2025
Ophthalmology, Te Whatu Ora Health New Zealand, Wellington, New Zealand
We present a case of systemic sarcoidosis presenting with mild blurred vision, limitation of left eye movements and choroidal infiltration around the left optic disc. Symptoms and signs of inflammation were absent, and secondary malignancy was suspected. After a prolonged series of investigations revealed multiple asymptomatic inflammatory lesions, subsequent lymph node biopsy revealed non-caseating granulomas.
View Article and Find Full Text PDFSpatial expression of HER2, NECTIN4, and TROP-2 in Muscle-Invasive Bladder Cancer and metastases: Implications for pathological and clinical management.
Mod Pathol
March 2025
Institute of Pathology, Charité Universitätsmedizin Berlin, Corporate Member of Frei Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health, Berlin, Germany. Electronic address:
Muscle-invasive bladder cancer (MIBC) presents significant treatment challenges. Antibody-drug conjugates (ADCs) targeting HER2, TROP-2, and NECTIN4 offer promising therapeutic options. This study examined the spatial expression of HER2, TROP-2, and NECTIN4 in MIBC and metastases, their association with molecular subtypes, and clinical outcomes.
View Article and Find Full Text PDFThe prognostic outcome of tumor deposit in colorectal cancer beyond stage N staging.
Surg Oncol
March 2025
Colorectal Division, Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Electronic address:
Background: Tumor deposits (TD) have been shown to have prognostic implications in patients diagnosed with colorectal cancer (CRC), although their impact appears to be modest compared to regional lymph node metastases.
Patients And Methods: A retrospective analysis was conducted involving patients with colorectal cancer in stages I-III who underwent curative resections between January 2015 and December 2019 in the tertiary care center in Thailand. These patients were divided into two cohorts: TD positive and TD negative.
Dietary succinate supplementation alleviates DSS-induced colitis via the IL-4Rα/Hif-1α Axis.
Int Immunopharmacol
March 2025
Department of Gastroenterology, Zhongshan Hospital of Xiamen University, Cancer Research Center & Institute of Microbial Ecology, School of Medicine, Xiamen University, Xiamen 361004, China; State Key Laboratory of Cellular Stress Biology, School of Life Science, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China. Electronic address:
Inflammatory bowel disease (IBD) remains a pressing global health challenge, necessitating novel therapeutic strategies. Succinate, a metabolite known for its role in type 2 immunity and tuft cell activation in the small intestine, presents its potential in IBD management. However, its impact on colonic inflammation has not been explored.
View Article and Find Full Text PDFDecision-Making for Ablation of Colorectal Liver Oligometastases Patients: A 10-Year Retrospective Study of Survival Outcomes Based on Right-Versus Left-Sided Primary Tumor Location.
Cancer Control
March 2025
Department of Interventional Ultrasound, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
ObjectiveTo develop a prognostic model for optimizing management of colorectal liver oligometastases (CLOM) patients with different primary tumor locations who underwent thermal ablation (TA).Materials and MethodsThe reporting of this retrospective study conforms to STROBE guidelines. A total of 525 CLOM patients who underwent TA from 3 hospitals between 2011 and 2021 were enrolled.
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