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The Genetics of IgA Nephropathy: Implications for Future Therapies.
Semin Nephrol
March 2025
Renal Division, Peking University First Hospital, Beijing, People's Republic of China; Kidney Genetics Center, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, People's Republic of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, People's Republic of China; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, People's Republic of China. Electronic address:
IgA nephropathy (IgAN), the most prevalent primary glomerulonephritis worldwide, carries a considerable lifetime risk of kidney failure. The etiology of IgAN, however, remains incompletely understood, and effective treatment is lacking. Although the multihit model effectively identifies key steps in IgAN development and, to date, provides the best description of IgAN pathogenesis, it remains under development to fully capture the complexity of immune system dysregulation.
View Article and Find Full Text PDFHyperglycemia-related risk factors in enteral nutrition in non-critically ill patients.
Endocrinol Diabetes Nutr (Engl Ed)
March 2025
Hospital Clínico Universitario de Valladolid, Universidad de Valladolid, Valladolid, Spain; Centro de Investigación en Endocrinología y Nutrición (IENVA), Universidad de Valladolid, Valladolid, Spain.
Introduction: Carbohydrate metabolism can change in hospitalized patients due to stress, or the use of enteral nutrition (EN). The aim of this study was to determine the risk factors triggering these changes.
Material And Methods: We conducted a retrospective observational study in non-diabetic patients with low levels of stress on EN.
Short bowel syndrome and d-lactic acidosis: A case report with supplemental home parenteral nutrition and teduglutide.
Endocrinol Diabetes Nutr (Engl Ed)
March 2025
Endocrinologia y Nutrición, Hospital Universitario de la Princesa, Calle Diego de León 62, 28007 Madrid, Spain.
d-Lactic acidosis is an uncommon cause of acidosis that occurs in patients with short bowel syndrome (SBS). Reduced intestinal absorption surface leads to carbohydrate malabsorption, fermented by abnormal colonic bacterial flora, resulting in elevated d-lactate levels. It should be suspected in SBS patients who exhibit typical neurological symptoms without other apparent causes, along with metabolic acidosis with normal l-lactate levels.
View Article and Find Full Text PDFAntibacterial mechanism of lysine against Escherichia coli O157:H7, its action on lettuce and in reducing the severity of murine colitis.
Food Microbiol
August 2025
College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, Yangling, 712100, Shaanxi, China. Electronic address:
The aim of the present study was to evaluate the mechanism of antimicrobial action of Lysine (Lys) against Escherichia coli (E. coli) O157:H7. Lys alters the permeability and morphology of bacterial cell membranes, leading to leakage of intracellular material.
View Article and Find Full Text PDFEnhancement of dry-hopped cider aroma through selection of apple cultivar, hop variety and yeast strain.
Food Microbiol
August 2025
Technische Universität Berlin, Institute of Food Technology and Food Chemistry, Chair of Brewing and Beverage Technology, Ackerstr. 76, 13355, Berlin, Germany.
Consumers increasingly seek more complex and tropical flavors in their alcoholic beverages. In beer and wine, yeast can release glutathione and cysteine-bound thiols from hops and grapes enhancing their tropical and fruity aromas. This study aimed to enhance cider aroma by combining yeast strains, hop and apple varieties.
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