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Impact of hyper- and hypothermia on cellular and whole-body physiology.
J Intensive Care
January 2025
Department of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, NC, USA.
The incidence of heat-related illnesses and heatstroke continues to rise amidst global warming. Hyperthermia triggers inflammation, coagulation, and progressive multiorgan dysfunction, and, at levels above 40 °C, can even lead to cell death. Blood cells, particularly granulocytes and platelets, are highly sensitive to heat, which promotes proinflammatory and procoagulant changes.
View Article and Find Full Text PDFDiagnosis of Multiple Organ Dysfunction in Neonates with Hypoxic-Ischemic Encephalopathy: Vasoactive Inotropic Score, Renal Score, Fibrosis-5 Index and Lactate/Albumin Ratio.
Diagnostics (Basel)
December 2024
Department of Neonatology, Dr. Sami Ulus Maternity and Child Research and Training Hospital, Babur st., Number: 36, Altındag 06080, Turkey.
Background: Vasoactive inotrope score, renal score, fibrosis-5 index, and lactate-albumin ratio have not been investigated before in determining multiple organ dysfunctions accompanying infants with hypoxic-ischemic encephalopathy (HIE) in neonatal intensive care units (NICUs). The aim of this study was to determine whether multiple organ dysfunctions that may accompany HIE in infants are correlated with vasoactive inotrope score (VIS), renal score (RS), fibrosis-5 index (FIB-5), and lactate-albumin ratio (LAR), and whether these parameters can predict morbidity and mortality.
Methods: This is a retrospective study, and 106 newborns diagnosed with HIE and treated with hypothermia were included in the study.
Phosphorylation state of Akt in the heart during artificial deep hypothermia in Syrian hamsters.
J Vet Med Sci
December 2024
Laboratory of Veterinary Physiology, Faculty of Applied Biological Sciences, Gifu University.
Article Synopsis
- Hibernating animals can significantly lower their body temperature without damaging their organs, potentially due to active hypometabolism.
- Researchers studied the phosphorylation of Akt to see if metabolism decreases during artificial hypothermia in hamsters.
- They found that while hypothermia through adenosine A1 receptor activation decreased Akt phosphorylation significantly, anesthesia-induced hypothermia showed only partial reduction without organ damage, indicating both methods allow for regulated metabolic reduction.
Body size influences the capacity to cope with extreme cold or hot temperatures in the striped hamster.
J Therm Biol
December 2024
College of Life and Environmental Science, Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, Wenzhou University, Wenzhou, 325035, China. Electronic address:
Body size of organisms is a key trait influencing nearly all aspects of their life history. Despite growing evidence of Bergmann's rule, there is considerably less known about the links between body size and the maximum capacity to thermoregulate of an animal in response to extreme cold or hot environment. Thermal characteristics such as resting metabolic rate (RMR) and non-shivering thermogenesis (NST), and the upper- and lower-critical temperatures of the thermal neutral zone (TNZ) were investigated in small and large body sized striped hamsters (Cricetulus barabensis).
View Article and Find Full Text PDFTorpor is a state used by several mammals to survive harsh winters and avoid predation, characterized by a drastic reduction in metabolic rate followed by a decrease in body temperature, heart rate, and many physiological variables. During torpor, all organs and systems must adapt to the new low-energy expenditure conditions to preserve physiological homeostasis. These adaptations may be exploited in a translational perspective in several fields.
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