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Metabolic Characteristics of Sclera in Lens-Induced Myopic Guinea Pigs.
Invest Ophthalmol Vis Sci
November 2024
Shanghai Institute of Infectious Disease and Biosecurity, Zhongshan Hospital, Fudan University, Shanghai, China.
Article Synopsis
- Myopia in guinea pigs was induced using special lenses, and researchers investigated the metabolic changes in the sclera, focusing particularly on amino acid levels.
- Metabolomic analyses revealed significant alterations in metabolic pathways linked to myopia, highlighting reductions in specific amino acids in the affected sclera.
- Supplementing with glycine was found to counteract some effects of myopia, increasing collagen levels, inhibiting eye elongation, and reversing changes in certain proteins associated with this condition.
Mastoid approach for local drug delivery to the inner ear for treating hearing loss.
J Control Release
December 2024
Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China. Electronic address:
Hearing loss is a prevalent disability worldwide. Dexamethasone (Dex) is commonly used to treat hearing loss, administered either systemically or locally. However, targeted delivery of Dex to the inner ear remains challenging, which limits its therapeutic efficacy.
View Article and Find Full Text PDFLentil Waste Extracts for Inflammatory Bowel Disease (IBD) Symptoms Control: Anti-Inflammatory and Spasmolytic Effects.
Nutrients
September 2024
Department of Pharmacy-Drug Sciences, University Aldo Moro-Bari, 70126 Bari, Italy.
Article Synopsis
- Researchers examined lentil seed coats for their health benefits, particularly in managing inflammatory bowel diseases (IBDs).
- They used both traditional and microwave-assisted extraction methods to obtain extracts, finding the microwave method with ethyl acetate the most effective for anti-inflammatory and spasmolytic activity.
- The study concluded that this extract could support intestinal health, indicating its potential as a dietary supplement to help treat intestinal issues.
Effect of integrated pest management practices on the occurrence of pesticide residue in okra cultivated by farmers in Kwara state.
Environ Monit Assess
October 2024
Department of Crop Protection, University of Ilorin, Ilorin, Kwara State, Nigeria.
Integrated pest management (IPM) is a sustainable approach for minimizing the negative impacts of pests on crops while reducing reliance on synthetic pesticides. This study was conducted in Kwara State Nigeria in 2023, to investigate the effects of implementation of IPM practices on the occurrence of pesticide residues in okra cultivated by the farmers in Kwara State, Nigeria, and identify the factors affecting the use of IPM practices for pest control in okra production. A sample of 245 okra farmers was selected across 4 agricultural zones of Kwara State using a multistage sampling technique.
View Article and Find Full Text PDFMolded Round Window Niche Implant as a Dexamethasone Delivery System in a Cochlear Implant-Trauma Animal Model.
Pharmaceutics
September 2024
Department of Otolaryngology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Background: Preserving residual hearing after cochlear implant (CI) surgery remains a crucial challenge. The application of dexamethasone (DEX) has been proven to positively affect residual hearing. To deliver DEX in a localized and controlled way, a round window niche implant (RNI), allowing drug diffusion via the round window membrane into the cochlea, may be used.
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