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New insights into the putative role of leucine-rich repeat proteins of and their participation in host cell invasion: an analysis.
Front Cell Infect Microbiol
December 2024
Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, Brazil.
Pathogenic are spirochetes that cause leptospirosis, a worldwide zoonotic disease. Leptospirosis affects humans and animals, with approximately 1 million human infections and 60,000 deaths per year. The diversity of leptospiral strains and serovars allied to the fact that pathogenesis is not yet fully understood, make the development of an effective vaccine against leptospirosis a challenge.
View Article and Find Full Text PDFIn silico prediction and experimental evaluation of LIP3228 of pathogenic Leptospira as a potential subunit vaccine target against leptospirosis.
Biochem Biophys Res Commun
January 2025
Chula Vaccine Research Center (Chula VRC), Center of Excellence in Vaccine Research and Development, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand; Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand. Electronic address:
A protein subunit vaccine comprising conserved surface-exposed outer membrane proteins (SE-OMPs) is considered a promising platform for leptospirosis vaccine. The search for novel vaccine candidates that confer high protective efficacy against leptospirosis is ongoing. The LIP3228 protein was previously identified as a conserved and abundant SE-OMP with the potential to serve as an effective vaccine candidate.
View Article and Find Full Text PDFUrinary leptospiral sphingomyelinases as diagnostic markers of leptospirosis in dengue patients co-infected with leptospirosis.
Diagn Microbiol Infect Dis
December 2024
Department of Animal Biology, School of Life Sciences, University of Hyderabad, Prof. CR Rao Road, Gachibowli, Hyderabad 500 046, India. Electronic address:
The study aims to evaluate the diagnostic potential of pathogen-specific leptospiral sphingomyelinases, LipL32, LipL41, and HbpA in human patients with dengue-leptospirosis coinfection. Patients (n-86), upon clinical evaluation, were categorized into Group I (n-37; leptospirosis), Group II (n-39; dengue-leptospirosis coinfection), and Group III (n-10; negative for both dengue and leptospirosis). ELISA identified significant levels of the four leptospiral antigens in the urine of Group I and II, but not in Group III patients.
View Article and Find Full Text PDFImmunological characterization of recombinant outer membrane Loa22 protein of local pathogenic serovars.
Vet Res Forum
October 2024
Department of Immunology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.
Leptospirosis is a worldwide zoonotic disease caused by pathogenic spp, often occurring in tropical and subtropical regions. Focusing on development of rapid diagnostic methods to facilitate early diagnosis and a universal vaccine are the main critical issues to overcome the burden of leptospirosis. Here, we have studied the immunogenic potential of prepared recombinant Loa22 protein (rLoa22) of local pathogenic species in mice and its ability to induce humoral and cellular immunity, being further evaluated by analyzing the immunoglobulin G (IgG) subclasses and cytokines produced through immunization.
View Article and Find Full Text PDFCoinfection with Orthohantavirus and spp. in Rats Collected from Markets in Indonesia.
Vector Borne Zoonotic Dis
January 2025
Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.
Article Synopsis
- * A study found that 30% of Rattus norvegicus tested positive for Seoul hantavirus (SEOV), with 12.5% showing coinfection with Leptospira.
- * Immunohistochemical analyses showed distinct locations for hantavirus and Leptospira in rat kidneys, highlighting the high prevalence of these pathogens and the potential public health risks they pose in the region.
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