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Heme promotes venetoclax resistance in multiple myeloma through MEK-ERK signaling and purine biosynthesis.
Blood
December 2024
Winship Cancer Institute, Emory University, Atlanta, Georgia, United States.
We previously demonstrated that reduced intrinsic electron transport chain (ETC) activity predicts and promotes sensitivity to the BCL-2 antagonist, venetoclax (Ven) in multiple myeloma (MM). Heme, an iron-containing prosthetic group, and metabolite is fundamental to maintaining ETC activity. Interrogation of the CD2 subgroup of MM from the CoMMpass trial (NCT01454297), which can be used as a proxy for Ven-sensitive MM (VS MM), shows reduced expression of the conserved heme biosynthesis pathway gene signature.
View Article and Find Full Text PDFGinsenoside Rb1 targets to HO-1 to improve sepsis by inhibiting ferroptosis.
Free Radic Biol Med
January 2025
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China; Beijing Institute of Traditional Chinese Medicine, Beijing, 100010, China; Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases, Beijing, 100010, China. Electronic address:
Sepsis remains the leading cause of mortality among Intensive Care Unit (ICU) patients, with its pathogenesis and treatment not yet fully elucidated. Ferroptosis plays a critical role in sepsis, suggesting that ferroptosis-related genes may serve as potential therapeutic targets. This study aims to identify key ferroptosis-related genes in sepsis and explore targeted therapeutics.
View Article and Find Full Text PDFDistribution of protoporphyrin IX during Prorocentrum donghaiense blooms and its relationship with particle-attached and free-living bacterial communities.
Environ Res
December 2024
State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, 361102, China. Electronic address:
Particle-attached (PA) and free-living (FL) bacterial communities are essential for nutrient cycles and metabolite production and serve as a food source in aquatic systems. However, our understanding of how biotic factors influence community interactions, co-occurrence patterns, and niche occupancy remains limited. This study investigated the influence of protoporphyrin IX (PPIX) on bacteria with different lifestyles during Prorocentrum donghaiense bloom.
View Article and Find Full Text PDFCombined use of 5-ALA-induced protoporphyrin IX and chlorin e6 for fluorescence diagnostics and photodynamic therapy of skin tumors.
Lasers Med Sci
October 2024
Prokhorov General Physics Institute, Moscow, Russian Federation.
Different types of photosensitizers (PSs) have different dynamics and intensities of accumulation, depending on the type of tumor or different areas within the same tumor. This determines the effectiveness of fluorescence diagnostics and photodynamic therapy (PDT). This paper studies the processes of 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) and chlorin e6 (Ce6) accumulation in the central and border zones of a tumor after combined administration of two PSs into the patient's body.
View Article and Find Full Text PDFUse of a Single-Fiber Optical Probe for the Detection of Tumor Fluorescence in High-Grade Glioma.
Oper Neurosurg (Hagerstown)
October 2024
Department of Neurosurgery, Cork University Hospital, Cork, Ireland.
Background And Objectives: High-grade glioma (HGG) is the most common primary brain tumor in adults. The overall median survival is between 14 and 16 months. Fluorescence-guided surgery by detection of protoporphyrin IX (PpIX) fluorescence has been shown to improve the extent of resection, translating to improved progression-free survival.
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