Background And Design: The assessment of cutaneous wound healing in humans has been hampered by the inability to evaluate multiple wounds with identical origins, treatment histories, and sizes. There have been no double-blind wound healing studies in humans that compared one wound dressing with another. The purpose of this study was to determine if identical suction blister wounds could serve as a model to evaluate and compare wound healing and overall cosmetic appearance of wounds treated with commercially available adhesive bandages. In a double-blind study, we compared superficial skin wounds of identical depth and diameter, created on the forearms of five human subjects by means of a suction blister device. The wounds were covered by two common, commercially available adhesive bandages or a copolymer of polyurethane membrane type of wound dressing. We compared the degree of reepithelialization, erythema, skin depression, and overall cosmetic appearance of wounds with respect to the specific adhesive bandages used.
Results: The wounds covered with the copolymer of polyurethane membrane were judged to have better overall appearance and advanced reepithelialization compared with identical wounds covered by the other wound dressings. With the use of x5 magnification for viewing the wounds on the final day of evaluation (between days 18 and 22), the wounds treated with the copolymer of polyurethane membrane were judged to be the least depressed wounds in fields of identical wounds in the three subjects studied. Concordance between the evaluators' "blinded" assessments was uniform, and no discrepancy between the evaluators' assessments occurred at any of the time points.
Conclusion: Identical wounds created with a suction blistering device can be used reliably to detect differences between the performances of wound dressings in healing superficial wounds. Superficial cutaneous wounds covered with a copolymer of polyurethane dressing demonstrated a superior rate of reepithelialization, less depression, and a better overall cosmetic appearance than wounds covered with two commercially available adhesive bandages.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Multiple crosslinked, self-healing, and shape-adaptable hydrogel laden with pain-relieving chitosan@borneol nanoparticles for infected burn wound healing.
Theranostics
January 2025
Department of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, Shaanxi, China.
Next-generation wound dressings with multiple biological functions hold promise for addressing the complications and pain associated with burn wounds. A hydrogel wound dressing loaded with a pain-relieving drug was developed for treating infected burn wounds. Polyvinyl alcohol chemically grafted with gallic acid (PVA-GA), sodium alginate chemically grafted with 3-aminobenzeneboronic acid (SA-PBA), Zn, and chitosan-coated borneol nanoparticles with anti-inflammatory and pain-relieving activities were combined to afford a nanoparticle-loaded hydrogel with a PVA-GA/Zn/SA-PBA network crosslinked via multiple physicochemical interactions.
View Article and Find Full Text PDFAn antimicrobial and adhesive conductive chitosan quaternary ammonium salt hydrogel dressing for combined electrical stimulation and photothermal treatment to promote wound healing.
Carbohydr Polym
March 2025
Hubei Key Laboratory for Precision Synthesis of Small Molecule Pharmaceuticals, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, School of Material Science and Engineering, Hubei University, Wuhan 430062, China. Electronic address:
The aim of this study is to investigate the effect of the adhesive, conductive hydrogel on wound healing when used as a therapeutic dressing. Herein, a dressing of PVA/QCS/TP@Fe (PQTF) was designed and prepared integrating polyvinyl alcohol (PVA), chitosan quaternary ammonium salt (QCS), tea polyphenol (TP), and ferric ions (Fe) by a simple one-pot and freeze-thaw method. In view of the comprehensive properties of PQTF hydrogel, including adhesion, electrical conductivity, and swelling performance, PQTF was selected for subsequent in vitro and in vivo healing promotion studies.
View Article and Find Full Text PDFA self-elastic chitosan sponge reinforced with lauric acid-modified quaternized chitosan and attapulgite to treat noncompressible hemorrhage and facilitate wound healing.
Carbohydr Polym
March 2025
Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China. Electronic address:
The development of self-elastic sponges with enhanced hemostatic and antibacterial properties to treat noncompressible hemorrhage and facilitate wound healing remains challenging. Herein, we prepared a chitosan sponge reinforced with lauric acid-modified quaternized chitosan (LQC) and attapulgite, features a porous structure, high self-elasticity, and rapid shape recovery. The incorporation of LQC conferred the sponge with an enhanced capacity to promote the adhesion, aggregation, and activation of blood cells, and resistance to infection by Staphylococcus aureus, Escherichia coli, and Methicillin-resistant Staphylococcus aureus; the incorporation of attapulgite enhanced the hydrophilicity and mechanical strength of the sponge, and its ability to activate the intrinsic and extrinsic coagulation pathways.
View Article and Find Full Text PDFSelf-Healing Oxidized Dextran/Sodium Alginate Hydrogel Dressing with Hemostatic Activity Speeds Up Wound Healing in Burn Injuries.
ACS Appl Mater Interfaces
January 2025
College of pharmacy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China.
This study introduced a hydrogel dressing, termed SODex-gel, which was constructed by establishing Schiff base and hydrogen bonds with the precursors of oxidized dextran (ODex) and succinic dihydrazide (SD)-modified sodium alginate (SD--SA). Through comprehensive and studies, the adhesive properties, self-healing capabilities, hemostatic potential, and wound healing efficacy of the SODex-gel dressing were meticulously evaluated. The H NMR, FTIR, and TGA analyses confirmed the fabrication of the SODex-gel dressing and its constituent elements.
View Article and Find Full Text PDFMulti-crosslinking nanoclay/oxidized cellulose hydrogel bandage with robust mechanical strength, antibacterial and adhesive properties for emergency hemostasis.
J Colloid Interface Sci
December 2024
College of Marine Life Sciences, Ocean University of China, No. 5 Yushan Road, Qingdao 266003, China. Electronic address:
Emergency bleeding presents significant challenges such as high blood flow and rapid hemorrhaging. However, many existing hemostatic bandages face limitations, including the uncontrolled release of hemostatic agents, insufficient mechanical strength, poor adhesion, and complex manufacturing processes. To address these limitations, we developed a multifunctional hydrogel bandage for emergency hemostasis using a one-pot synthesis method.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!