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Early achievement of hemostasis defined by transfusion velocity: A possible mechanism for whole blood survival benefit.
J Trauma Acute Care Surg
January 2025
From the Department of Surgery (A.M.C., L.V., A.L.C.), University of Pittsburgh; University of Pittsburgh School of Public Health (J.F.L., S.R.W.); Department of Emergency Medicine (F.X.G.), University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Surgery (B.A.C.), University of Texas Health Science Center, Houston, Texas; Department of Surgery (J.W.C.), University of Pennsylvania, Philadelphia, Pennsylvania; Department of Surgery (M.A.S.), Oregon Health & Science University, Portland, Oregon; Department of Surgery (E.E.M.), Ernest E. Moore Shock Trauma Center at Denver Health, University of Colorado Health Sciences Center, Denver, Colorado; Department of Surgery (N.N.), University of Miami/Jackson Memorial Hospital, Miami, Florida; Department of Surgery (J.P.M.), University of Texas Southwestern Medical Center, Dallas, Texas; and Department of Pathology (M.H.Y.), Department of Radiology (V.A.), and Trauma and Transfusion Medicine Research Center, Department of Surgery (J.B.B., C.M.L., M.D.N., R.M.F., J.L.S.), University of Pittsburgh, Pittsburgh, Pennsylvania.
Introduction: Whole blood resuscitation is associated with survival benefits in observational cohort studies. The mechanisms responsible for outcome benefits have not been adequately determined. We sought to characterize the achievement of hemostasis across patients receiving early whole blood versus component resuscitation.
View Article and Find Full Text PDFCoumarin Analogues as Promising Anti-Obesity Agents: In Silico Design, Synthesis, and In Vitro Pancreatic Lipase Inhibitory Activity.
Chem Biol Drug Des
January 2025
Laboratory of Natural Product Chemistry, Department of Pharmacy, Birla Institute of Technology and Science, Pilani (BITS Pilani), Pilani, Rajasthan, India.
A set of coumarin-3-carboxamide analogues were designed, synthesized, and evaluated for their ability to impede pancreatic lipase (PL) activity. Out of all the analogues, 5dh and 5de demonstrated promising inhibitory activity against PL, as indicated by their respective IC values of 9.20 and 11.
View Article and Find Full Text PDFBiotechnological Phytocomplex of (L.) DC. Enhances Collagen Biosynthesis In Vitro and Improves Skin Elasticity In Vivo.
Pharmaceutics
January 2025
Department of Physical Sciences, Earth and Environment, University of Siena, 53100 Siena, SI, Italy.
(L.) DC., commonly known as Japanese pepper, is a deciduous shrub native to East Asia.
View Article and Find Full Text PDFBehavior of Olive Genotypes Against Quick Decline Syndrome (QDS) Caused by subsp. in Apulia.
Plants (Basel)
January 2025
Department of Soil, Plant and Food Sciences (DiSSPA), University of Bari-Aldo Moro, Via Giovanni Amendola 165/A, 70126 Bari, Italy.
subsp. (), a quarantine pathogen in the European Union, severely threatens Mediterranean olive production, especially in southern Italy, where Olive Quick Decline Syndrome (OQDS) has devastated Apulian olive groves. This study addresses the urgent need to identify resistant olive genotypes by monitoring 16 potentially tolerant genotypes over six years, assessing symptom severity and bacterial load.
View Article and Find Full Text PDFLong-Term Clinical Impact of Paravalvular Leak Following Transcatheter Aortic Valve Implantation.
J Clin Med
January 2025
National Center for Global Health, Istituto Superiore di Sanitá, 00161 Rome, Italy.
Paravalvular leak (PVL) was initially recognized as one of the most common complications after transcatheter aortic valve implantation (TAVI) and has been linked to adverse clinical outcomes, including mortality. This study aims to assess the long-term clinical effects of PVL in patients undergoing TAVI with the latest generation of transcatheter aortic valves, as part of the national observational prospective multicenter study OBSERVANT II. OBSERVANT II included all consecutive patients with severe aortic stenosis who underwent TAVI across 28 Italian centers from December 2016 to September 2018.
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