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Analytical Investigation of the Profile of Human Chorionic Gonadotropin in Highly Purified Human Menopausal Gonadotrophin Preparations.
Int J Mol Sci
August 2024
Global Medical Affairs-Fertility, Merck KGaA, 64293 Darmstadt, Germany.
Highly purified human menopausal gonadotropin (HP-hMG [Menopur, Ferring Pharmaceuticals, Saint-Prex, Switzerland]) contains a 1:1 ratio of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This analysis aimed to assess gonadotropin (FSH, LH and hCG) abundance in HP-hMG and clarify the source of hCG by assessing the presence of sulfated glycans, which are diagnostic for pituitary hCG forms due to their distinct glycosylation patterns. Additionally, the purity of each sample, their specific components, and their oxidation levels were assessed.
View Article and Find Full Text PDFAlterations in the gut microbiota community are associated with childhood obesity and precocious puberty.
BMC Microbiol
August 2024
Department of Pediatric Research Institute, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics Metabolism and Inflammatory Disease, Children's Hospital of Chongqing Medical University, Chongqing, China.
Article Synopsis
- - The study investigates how the gut microbiota differs between girls with obesity-related precocious puberty, those with precocious puberty, and healthy children, discovering significant variations in microbial diversity among these groups.
- - Specific types of bacteria, such as Bifidobacterium and Anaerostipes, were identified as key biomarkers that correlate with obesity-related precocious puberty, indicating potential relationships between gut health and hormonal development.
- - Findings suggest that certain gut bacteria might influence weight and hormonal levels, pointing to the potential for microbiome-based interventions in managing obesity and precocious puberty in clinical settings.
Association between sex hormones and erectile dysfunction in men without hypoandrogenism.
Sci Rep
June 2024
Department of Urology, Hirosaki University Graduate School of Medicine, 5-Zaifucho, Hirosaki, 036-8562, Japan.
In addition to testosterone, various endocrine hormones, such as dehydroepiandrosterone sulfate (DHEA-S) and estradiol, may be involved in erectile function. However, the role of these sex hormones in the erectile function of men without hypoandrogenism remains unclear. This cross-sectional study included 398 community-dwelling men without hypoandrogenism.
View Article and Find Full Text PDFCharacterization of the gut microbiota in polycystic ovary syndrome with dyslipidemia.
BMC Microbiol
May 2024
Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.
Background: Polycystic ovary syndrome (PCOS) is an endocrinopathy in childbearing-age females which can cause many complications, such as diabetes, obesity, and dyslipidemia. The metabolic disorders in patients with PCOS were linked to gut microbial dysbiosis. However, the correlation between the gut microbial community and dyslipidemia in PCOS remains unillustrated.
View Article and Find Full Text PDFSystematic review and meta-analysis of serum total testosterone and luteinizing hormone variations across hospitalized Covid-19 patients.
Sci Rep
February 2024
Department of Maternal Infant and Urologic Sciences, "Sapienza" University of Rome, Policlinico Umberto I Hospital, 00161, Rome, Italy.
A growing body of evidence suggests the role of male hypogonadism as a possible harbinger for poor clinical outcomes across hospitalized Covid-19 patients. Accordingly, we sought to investigate the impact of dysregulated hypothalamic-pituitary-gonadal axis on the severity of the clinical manifestations for hospitalized Covid-19 patients matched with healthy controls through a systematic review and meta-analysis. Databases were searched from inception to March 2022.
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