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Tuning chitosan properties to enhance blood coagulation.
Int J Biol Macromol
January 2025
Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russia.
The search for new hemostatic materials remains a priority for researchers, as the problem of uncontrolled hemorrhage during surgical interventions or traumatic injuries represents a significant challenge. The objective of the study was to identify novel polysaccharide structures with enhanced hemostatic properties based on chitosan. The number of chitosan derivatives with two substituents was synthesized and characterized by H NMR, FTIR.
View Article and Find Full Text PDFIdentification of potential biomarkers and pathways involved in high-altitude pulmonary edema using GC-MS and LC-MS metabolomic methods.
Sci Rep
December 2024
Department of Intensive Care Unit, The 940 Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, China.
High-altitude pulmonary edema (HAPE) is a life-threatening altitude sickness afflicting certain individuals after rapid ascent to high altitude above 2500 m. In the setting of HAPE, an early diagnosis is critical and currently based on clinical evaluation. The aim of this study was to utilize the metabolomics to identify the altered metabolic patterns and potential biomarkers for HAPE.
View Article and Find Full Text PDFPreventive effect of aminocaproic acid combined with nimodipine on short-term rebleeding in patients with aneurysmal subarachnoid hemorrhage.
Neuroreport
February 2025
Department of Neurology, The People's Hospital of Anyang City, Anyang, Henan Province, China.
Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening and life-limiting disease with high mortality and disability rates. Herein, we aim to explore the preventive effect of aminocaproic acid combined with nimodipine on short-term rebleeding in patients with aSAH. Retrospectively, the medical data of patients with aSAH ( n = 256) were collected.
View Article and Find Full Text PDFComputation-driven redesign of an NRPS-like carboxylic acid reductase improves activity and selectivity.
Sci Adv
November 2024
State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.
Article Synopsis
- - The study focuses on enhancing nonribosomal peptide synthetases (NRPSs) due to their significant potential in synthetic biology, despite limited knowledge of their functions.
- - Researchers used computational methods to redesign the "gate-keeper" adenylation domain in a model enzyme, achieving substantial boosts in efficiency and specificity in converting certain acids.
- - The findings suggest improved biocatalysts for producing nylon monomers and offer a new strategy for engineering NRPSs more effectively.
Exploitation of the fibrinolytic system by B-cell acute lymphoblastic leukemia and its therapeutic targeting.
Nat Commun
November 2024
Institute of Transfusion Medicine - Transfusion Center, Johannes Gutenberg University Medical Center, 55131, Mainz, Germany.
Article Synopsis
- Fibrinolysis plays a crucial role in the release of hematopoietic stem cells from bone marrow, affecting the development of B-cell acute lymphoblastic leukemia (B-ALL).
- Activation of plasmin, driven by annexin A2, alters the extracellular matrix (ECM), which impacts cancer cell growth by trapping the growth factor IGF1 and hindering signaling pathways.
- Inhibiting plasmin activation with ε-aminocaproic acid (EACA) shows promise in reducing tumor size and extending survival in B-ALL models, suggesting that targeting fibrinolysis could be a helpful addition to cancer treatment.
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