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Rev Med Suisse
January 2025
Avec la collaboration du groupe MIAjour, Service de médecine interne, Centre hospitalier universitaire vaudois. Lausanne.
Narrative review of recent developments and the future of penicillin allergy de-labelling by non-allergists.
NPJ Antimicrob Resist
July 2024
Healthcare associated infection group, Leeds institute of medical research, university of Leeds, Leeds, UK.
This article outlines recent developments in non-allergist delivered penicillin allergy de-labelling (PADL), discusses remaining controversies and uncertainties and explores the future for non-allergist delivered PADL. Recent developments include national guidelines for non-allergist delivered PADL and validation of penicillin allergy risk assessment tools. Controversies remain on which penicillin allergy features are low risk of genuine allergy.
View Article and Find Full Text PDFA rapid literature review of the impact of penicillin allergy on antibiotic resistance.
JAC Antimicrob Resist
February 2025
Department of Microbiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Background: Antimicrobial resistance (AMR) is caused by the use and misuse of antibiotics. AMR is a global health concern, to which penicillin allergy (penA) labels appear to contribute. Patients who have penA labels are treated with non-penicillin antibiotics and receive more antibiotics when compared with patients without penA.
View Article and Find Full Text PDFAssociation between penicillin allergy labels and serious adverse events in hospitalized patients: a systematic review and meta-analysis.
Front Pharmacol
January 2025
Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Background: To date, several studies have demonstrated that erroneous labeling of Penicillin allergy (PAL) can significantly impact treatment options and result in adverse clinical outcomes, while other studies have reported no negative effects. Therefore, to systematically evaluate these effects and investigate the association between adverse clinical outcomes and the Penicillin label, we conducted this meta-analysis.
Method: Searches were conducted in the PubMed, Embase, Cochrane Library, and Web of Science databases from inception to 13 July 2024.
Improving cefazolin administration for surgical prophylaxis in reported penicillin allergy: A retrospective study of a health system intervention.
J Allergy Clin Immunol Glob
February 2025
Section of Rheumatology, Allergy, and Immunology, Department of Internal Medicine, Yale School of Medicine, New Haven, Conn.
Background: Cefazolin is the most common first-line antibiotic to prevent surgical-site infections. Patients with penicillin allergy labels often receive alternative antibiotics, which is associated with increased rates of surgical-site infections, multi-drug-resistant infections, and cost.
Objective: We sought to determine whether a hospital-wide guideline recommending first-line surgical prophylaxis in patients with penicillin allergy labels can increase the use of cefazolin without compromising safety.
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