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Iron balance following recombinant human erythropoietin therapy for anemia associated with chronic renal failure.
Int J Hematol
June 1991
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Erythrokinetic changes before and after rHuEPO therapy in 15 anemic patients with chronic renal failure undergoing maintenance hemodialysis were analyzed by means of ferrokinetics and measurement of red cell mass and survival. To estimate the change in iron status no exogenous iron was administered during the observation period unless a lack of response due to iron deficiency was confirmed. During 13-29 weeks of therapy there was an increase in red cell mass from 12.
View Article and Find Full Text PDFEpoetin alfa (EPOGEN, recombinant human erythropoietin) has proven to be a major therapeutic advance in treating the chronic refractory anemia associated with end-stage renal disease (ESRD). As with many medications, the dose of Epoetin alfa must be individualized for each patient. In order to elicit a consistent production of red cells from the bone marrow, it is desirable that dose modifications be made as infrequently as possible.
View Article and Find Full Text PDFSubcutaneous administration of recombinant human erythropoietin to subjects on continuous ambulatory peritoneal dialysis: an erythrokinetic assessment.
Br J Haematol
June 1990
Section of Haematology, Clinical Research Centre, Harrow, Middlesex.
Erythrokinetic studies were performed in subjects on continuous ambulatory peritoneal dialysis, during a trial examining the effectiveness of subcutaneous administration of recombinant human erythropoietin (r-HuEPO) in correcting the anaemia associated with end stage renal disease. 15 subjects (mean haemoglobin concentration 6.9 g/dl, SD 1.
View Article and Find Full Text PDFCharacterization of the anaemia of chronic renal failure and the mode of its correction by a preparation of human erythropoietin (r-HuEPO). An investigation of the pharmacokinetics of intravenous erythropoietin and its effects on erythrokinetics.
Q J Med
February 1989
Section of Haematology, Clinical Research Centre, Harrow, Middlesex.
Studies were directed to characterization of the anaemia of renal failure of 11 patients on haemodialysis and determination of the way in which it is corrected by human erythropoietin derived from recombinant DNA expressed in Chinese hamster ovary cells (r-HuEPO) administered intravenously. Erythrokinetics before treatment showed that total red cell mass was below normal and that both erythron transferrin uptake and red cell survival were modestly reduced; treatment increased both total red cell mass and erythron transferrin uptake but did not change red cell survival in previously untransfused patients. When BFU-e and CFU-e from patient bone marrow were cultured in autologous serum we found no evidence for inhibitors of erythroid progenitor maturation in patient serum compared with normal.
View Article and Find Full Text PDFKinetics of erythropoiesis in dialysis patients receiving recombinant erythropoietin treatment.
Nephrol Dial Transplant
October 1989
Service de Médecine Nucléaire, Hôpital S. Louis, Paris, France.
In eleven patients with uraemia on intermittent haemodialysis treatment, recombinant human erythropoietin (rHuEpo) was used at a dosage schedule of 100 IU/kg bodyweight thrice weekly. Erythrokinetic studies (blood volume, RBC survival and iron kinetics) were performed in nine cases before and after 6 months of treatment. The remaining two patients had only RBC and plasma volume determinations before and after treatment.
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