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http://dx.doi.org/10.1016/s0140-6736(64)90252-1 | DOI Listing |
Ann Allergy Asthma Immunol
March 2025
University Hospital of Reims, Immunology Laboratory, Biology and Pathology Department, Reims, France; University of Reims Champagne-Ardenne, INSERM UMR 1250, Reims, France. Electronic address:
Tryptase is currently the most specific mast cell biomarker available in clinical laboratories. Tryptase levels in peripheral blood contribute to the diagnostic, prognostic and therapeutic evaluation of three clinical categories: (1) immediate hypersensitivity reactions including the life-threatening systemic form known as anaphylaxis, (2) clonal mast cell diseases and other myeloid malignancies, including as a biomarker for efficacy of chemotherapeutic agents targeting mast cell survival, and (3) hereditary α-tryptasemia (HαT), a genetic trait found in 4 - 8% of general population associated to increased risk of severe immediate hypersensitivity reactions. Rapidly evolving pathophysiology knowledge and management guidelines impact tryptase use in clinical practice, explaining the need for frequent updates.
View Article and Find Full Text PDFCurr Opin Gastroenterol
March 2025
Academic Unit of Gastroenterology, Royal Hallamshire Hospital.
Purpose Of Review: Meckel's diverticulum (MD) is a common congenital ileal diverticulum. Whilst mostly asymptomatic, 4-9% develop complications, such as small bowel obstruction, diverticulitis or bleeding. In 1933, Charles Mayo wrote that MD is 'frequently suspected, often looked for and seldom found', and it continues to pose a diagnostic challenge today.
View Article and Find Full Text PDFFront Robot AI
February 2025
Center for Robotics, University of Bonn, Bonn, Germany.
Robust perception systems allow farm robots to recognize weeds and vegetation, enabling the selective application of fertilizers and herbicides to mitigate the environmental impact of traditional agricultural practices. Today's perception systems typically rely on deep learning to interpret sensor data for tasks such as distinguishing soil, crops, and weeds. These approaches usually require substantial amounts of manually labeled training data, which is often time-consuming and requires domain expertise.
View Article and Find Full Text PDFMater Today Bio
April 2025
Air Force Clinical College, The Fifth School of Clinical Medicine, Anhui Medical University, Hefei, 230032, China.
Bone defects resulting from trauma, tumor resection, non-union of fractures, and infections present enormous challenges in treatment. Although three-dimensional (3D) bioprinting plays an important role in repairing bone tissues, the lack of mechanical properties and osteoinductive ability of the bioinks remains a barrier for the application of the technology. In this study, we used advanced 3D bioprinting technology to create a novel piezoelectric hydrogel scaffold (Gel/PBT@BMSCs) which consisted of bone marrow-derived mesenchymal stem cells (BMSCs), gelatin methacryloyl (GelMA), and polyethylene glycol (PEG)-modified barium titanate (BT) nanoparticles.
View Article and Find Full Text PDFBMC Nurs
March 2025
Assistant Professor of Nursing, Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Heart valve replacement has many complications that affect patients and their family caregivers. Increasing patients' self-efficacy in dealing with complications and reducing the care burden of their caregivers are among the critical factors that impact their quality of life. Today, smartphone Apps allow access to reliable information without time and place restrictions.
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