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Intravenous administration of Y-labeled polyoxazoline combined with tumor heating potently inhibits tumor growth in mice.
Int J Pharm
January 2025
Laboratory of Biophysical Chemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558 Japan.
The basic requirements for the development of radiopharmaceuticals for radionuclide therapy of tumors include marked tumor-specific accumulation and long-term intratumoral retention. We have previously reported an indium-111 (In)-labeled thermoresponsive polymer (polyoxazoline (POZ)) that is soluble at body temperature with rapid clearance from normal tissues but self-aggregates in the tumor upon tumor heating treatment. POZ accumulated in the tumor via self-aggregation under hyperthermic conditions and was retained after stopping heat exposure.
View Article and Find Full Text PDFYttrium-90 radioembolization treatment strategies for management of hepatocellular carcinoma.
World J Radiol
October 2024
Department of Radiology, The Ohio State University Medical Center, Columbus, OH 43210, United States.
As the third leading cause of cancer-related deaths worldwide, hepatocellular carcinoma (HCC) represents a significant global health challenge. This paper provides an introduction and comprehensive review of transarterial radioembolization (TARE) with Yttrium-90 (Y90), a widely performed transcatheter procedure for HCC patients who are not suitable candidates for surgery. TARE involves the targeted delivery of radioactive microspheres to liver tumors, offering a promising treatment option for managing HCC across various stages of the disease.
View Article and Find Full Text PDFLI-RADS radiation-based treatment response algorithm for HCC: what to know and how to use it.
Abdom Radiol (NY)
October 2024
Memorial Sloan Kettering Cancer Center, New York, USA.
Locoregional treatments (LRT) continue to advance for hepatocellular carcinoma (HCC). Selective internal radiation therapy (SIRT) or transarterial radioembolization (TARE) with radioactive Yttrium (Y90) microspheres is currently widely accepted, and external beam and stereotactic body radiation (EBRT/SBRT) are increasingly used as LRT. Assessment of treatment response after these radiation-based therapies can be challenging, given that the adjacent liver also undergoes treatment related changes, inflammatory changes occur, and there is a variable time for response to develop.
View Article and Find Full Text PDFTransarterial radioembolization vs transarterial chemoembolization with drug-eluting beads for treating hepatocellular carcinoma: a cost-effectiveness analysis in Japanese healthcare system.
Jpn J Radiol
December 2024
Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Purpose: Transarterial radioembolization (TARE) is effective for unresectable hepatocellular carcinoma; however, it awaits approval in Japan. This study aimed to simulate the cost-effectiveness of TARE over chemoembolization when TARE is approved in Japan and identify the requirements for cost-effectiveness.
Materials And Methods: A Markov model was constructed to analyze the costs and effectiveness associated with TARE and transarterial chemoembolization with drug-eluting beads (DEB-TACE) for 2-month cycles over 5 years.
Polyoxometalate Ligands Reveal Different Coordination Chemistries Among Lanthanides and Heavy Actinides.
JACS Au
July 2024
Physical and Life Sciences Directorate, Glenn T. Seaborg Institute, Lawrence Livermore National Laboratory, Livermore, California 94550, United States.
Experimental studies involving actinide compounds are inherently limited in scope due to the radioactive nature of these elements and the scarcity and cost of their research isotopes. Now, ∼80 years after the introduction of the actinide concept by Glenn Seaborg, we still only have a limited understanding of the coordination chemistry of f-block metals when compared to more common elements such as the s-, p-, and d-blocks. This is particularly true for transplutonium actinides (Am, Cm, Bk, etc.
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