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Chronic moderate‑intensity exercise can induce physiological hypertrophy in aged cardiomyocytes through autophagy, with minimal Yap/Taz involvement.
Biomed Rep
March 2025
Physiology Molecular, Biological Activity Division, Central Laboratory, Sumedang, West Java 45363, Indonesia.
Aging is known to cause increased comorbidities associated with cardiovascular decline. Physical exercises were known to be an effective intervention for the age-associated decline in cardiac function. Exercise caused physiological hypertrophy influenced by Yap/Taz, autophagy and myosin heavy chain (MHC) dynamics.
View Article and Find Full Text PDFAge‑related changes in endoplasmic reticulum stress response‑associated protein expression in rat tibial nerves.
Biomed Rep
March 2025
Department of Physical Therapy, Faculty of Health Sciences, Kyoto Tachibana University, Kyoto 607-8175, Japan.
In age-related peripheral neurodegeneration, changes in the promotion or inhibition of endoplasmic reticulum (ER) stress response related to the ubiquitin-proteasome degradation system (UPS), autophagy and apoptosis signaling factors during aging remain unclear. In the present study, the expression of ER stress response signaling-related protein factors was examined in tibial nerves during aging in rats. Tibial nerves were extracted from continuously housed rats at 20, 50, 70, 90 and 105 weeks of age.
View Article and Find Full Text PDFAlteration in Oxidative Stress Enzymes and Proteins by Stramonium Hydroethanolic Root Extract Promotes Hippocampus and Cerebral Cortex Neurons Damage in Adult Sprague Dawley Rats.
Subst Abuse Rehabil
January 2025
Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University Wilberforce Island Bayelsa State, Amassoma, Nigeria.
Background: Datura metel is reported to induce hallucinations and mental disorders.
Objective: This study investigates the neurotoxic effects of stramonium hydroethanolic root extract on the hippocampus and cerebral cortex of adult rats using biochemical, histological and immunohistochemical techniques.
Methodology: Twenty five adult rats were assigned to 5 groups (n = 5 each).
The Mechanism of Acupuncture Therapy for Migraine: A Systematic Review of Animal Studies on Rats.
J Pain Res
January 2025
Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, People's Republic of China.
Background: Acupuncture has long been used for migraine treatment as it is convenient for use and has remarkable efficacy. The acupuncture-based comprehensive treatment plan has been widely recognized for migraine prevention and treatment. However, the mechanism underlying acupuncture efficacy in migraine treatment is not yet completely understood.
View Article and Find Full Text PDFPre-clinical acute oral toxicity and subacute neurotoxicity risk assessments on sprague dawley rats treated with single dose or repeated doses of flavonoid-enriched fraction extracted from leaves.
Drug Chem Toxicol
January 2025
School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
possesses promising flavonoid secondary metabolites. However, translation of these compounds into clinical practice for neurological disease treatment is halted as the toxicity and safety profile of the plant extracts are yet to be determined. This study was conducted to assess the acute oral toxicity and subacute neurotoxicity that could be imposed by the flavonoid-enriched fraction (FEF) extracted from leaves, by strictly following the procedures set in Organization for Economic Co-operation and Development (OECD) Guidelines No.
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