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Tunneling Nanotube-like Structures in .

Cells

September 2024

Laboratório de Ultraestrutura Celular Hertha Meyer, Centro de Pesquisa em Medicina de Precisão, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.

Article Synopsis
  • The text discusses a protozoan parasite that causes giardiasis, leading to symptoms like abdominal pain and diarrhea, primarily due to its ability to change surface proteins and evade the host's immune response.
  • High-resolution scanning microscopy revealed the formation of tunneling-nanotube-like structures on the parasite's surface, particularly when exposed to antibodies against its surface proteins.
  • These nanotubes play a role in communication, both among the parasites and with host cells, indicating a complex interaction in the gut environment.
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Exploration of small nucleolar RNAs (snoRNAs) and their possible microRNA derivatives.

Parasitology

May 2024

Department of Surgical Sciences, Uppsala University, BMC Box 593, Husargatan 3, 751 24, Uppsala, Sweden.

Small nucleolar RNAs (snoRNAs) are short non-coding RNAs that are abundant in the nucleoli of eukaryotic cells and play a crucial role in various aspects of ribosomal RNA (rRNA) maturation, including modifications such as 2′-O-methylation or pseudouridylation. On the other hand, is a microaerophilic, flagellated, binucleate protozoan responsible for causing giardiasis. Although numerous snoRNAs have been detected in , their investigation remains limited.

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is an important protozoan cause of diarrheal disease worldwide, delayed development and cognitive impairment in children in low- and middle-income countries, and protracted post-infectious syndromes in developed regions. resides in the lumen and at the epithelial surface of the proximal small intestine but is not mucosa invasive. The protozoan parasite is genetically diverse with significant genome differences across strains and assemblages.

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Multi-epitope protein production and its application in the diagnosis of opisthorchiasis.

Parasit Vectors

May 2024

College of Medicine and Public Health, Ubon Ratchathani University, Warinchamrap, 34190, Ubon Ratchathani, Thailand.

Background: Opisthorchiasis and cholangiocarcinoma (CCA) continue to be public health concerns in many Southeast Asian countries. Although the prevalence of opisthorchiasis is declining, reported cases tend to have a light-intensity infection. Therefore, early detection by using sensitive methods is necessary.

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