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Regulation of calcium homeostasis in endoplasmic reticulum-mitochondria crosstalk: implications for skeletal muscle atrophy.
Cell Commun Signal
January 2025
Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Road, Lu Zhou, Luzhou, Sichuan, 646000, China.
This review comprehensively explores the critical role of calcium as an essential small-molecule biomessenger in skeletal muscle function. Calcium is vital for both regulating muscle excitation-contraction coupling and for the development, maintenance, and regeneration of muscle cells. The orchestrated release of calcium from the endoplasmic reticulum (ER) is mediated by receptors such as the ryanodine receptor (RYR) and inositol 1,4,5-trisphosphate receptor (IP3R), which is crucial for skeletal muscle contraction.
View Article and Find Full Text PDFInvestigating skeletal muscle micro-trauma with time-dependent diffusion and the random permeable barrier model.
Sci Rep
December 2024
Amsterdam Movement Sciences, Sports, Amsterdam, The Netherlands.
Repeated muscle micro-trauma may cause severe muscle damage. Diffusion tensor imaging (DTI) exhibits sensitivity to microstructural changes in skeletal muscle. We hypothesize that longer diffusion times enhance sensitivity to micro-trauma and that membrane permeability increases with micro-trauma.
View Article and Find Full Text PDFControllable reconstruction of lignified biomass with molecular scissors to form carbon frameworks for highly stable Li metal batteries.
Chem Sci
December 2024
Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Material (Ministry of Education), Anhui University Hefei 230601 China
Lithium metal batteries (LMBs) promise high-energy-density storage but face safety issues due to dendrite-induced lithium deposition, irreversible electrolyte consumption, and large volume changes, which hinder their practical applications. To address these issues, tuning lithium deposition by structuring a host for the lithium metal anode has been recognized as an efficient method. Herein, we report a supercritical water molecular scissor-controlled strategy to form a carbon framework derived from biomass wood.
View Article and Find Full Text PDFNernst-Planck-Gaussian finite element modelling of Ca electrodiffusion in amphibian striated muscle transverse tubule-sarcoplasmic reticular triadic junctional domains.
Front Physiol
December 2024
Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom.
Introduction: Intracellular Ca signalling regulates membrane permeabilities, enzyme activity, and gene transcription amongst other functions. Large transmembrane Ca electrochemical gradients and low diffusibility between cell compartments potentially generate short-lived, localised, high-[Ca] microdomains. The highest concentration domains likely form between closely apposed membranes, as at amphibian skeletal muscle transverse tubule-sarcoplasmic reticular (T-SR, triad) junctions.
View Article and Find Full Text PDFThe Pathology of Intestinal Mucosal Disruption; Implications for Muscle Loss and Physical Dependency from Late Adolescence to Octogenarians.
Int J Gen Med
December 2024
Exercise Physiology Department, College of Sport Sciences and Physical Activity, King Saud University, Riyadh, 11451, Saudi Arabia.
Background And Objectives: A pathological increase in intestinal permeability causes muscle loss and physical decline by inducing systemic inflammation and oxidative stress. However, most relevant studies investigate older adults, and the appropriate data across age spans remain elusive. This study aimed to examine the associations of intestinal permeability with muscle loss and physical decline across a large span of ages.
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