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Purpose Of Review: The 2024 mpox outbreak, primarily driven by the possibly more virulent clade Ib strain, prompted the WHO declaring it a public health emergency of international concern (PHEIC) on August 14, 2024. This review provides essential guidance for clinicians managing mpox cases, as it contrasts the features of the 2024 outbreak with those of the 2022 epidemic to support better clinical decision-making.
Recent Findings: The review highlights significant differences between the 2024 and 2022 outbreaks, including total case numbers, demographic distribution, and fatality rates.
Transcriptomic and Proteomic Analysis of Monkeypox Virus A5L-Expressing HEK293T Cells.
Int J Mol Sci
January 2025
Institute of Pathogenic Microorganism, Jiangxi Agricultural University, Nanchang 330000, China.
Monkeypox (MPOX) is a zoonotic viral disease caused by the Monkeypox virus (MPXV), which has become the most significant public health threat within the genus since the eradication of the Variola virus (VARV). Despite the extensive attention MPXV has garnered, little is known about its clinical manifestations in humans. In this study, a high-throughput RNA sequencing (RNA-seq) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach was employed to investigate the transcriptional and metabolic responses of HEK293T cells to the MPXV A5L protein.
View Article and Find Full Text PDFMonkeypox (Mpox): Diagnosis and Emerging Challenges.
Yale J Biol Med
December 2024
Multidisciplinary Research Unit, Maulana Azad Medical College and Associated Hospital, New Delhi, India.
Monkeypox (Mpox) has once again been designated a Public Health Emergency of International Concern (PHEIC) as of August, 2024. The severity of the disease is underscored by its significant mortality rate, and unfortunately, there are no targeted therapeutics currently available for this viral infection. Management relies on preventive measures and the use of existing smallpox vaccines due to their genetic similarity to the Mpox virus.
View Article and Find Full Text PDFBurden and predictors of M-pox suspected cases in a rural setting of Cameroon: implications for developing countries.
J Infect Dev Ctries
November 2024
Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.
Article Synopsis
- M-pox is a rapidly spreading pathogen in developing countries, particularly in Cameroon, raising concerns about its health impact and the lack of data on its determinants.
- A community-based study conducted in the Ayos Health District found a suspected M-pox case rate of 25%, with various factors like history of infections and contact with infected individuals or animals significantly linked to its prevalence.
- The study highlights the need for enhanced surveillance and public health interventions in rural communities to better address the resurgence of M-pox.
Knowledge, Attitude, and Behavior of the Pakistani Population Toward the Monkeypox Pandemic and the Associated Factors.
Cureus
November 2024
Public Health, Health Services Academy, Islamabad, PAK.
Background Monkeypox (Mpox) is a virulent disease caused by orthopoxvirus. Mpox is emerging as a major global health threat. Currently, more than 100 countries are facing outbreaks.
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