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DISTING: A web application for fast algorithmic computation of alternative indistinguishable linear compartmental models.
Comput Methods Programs Biomed
May 2017
Biocybernetics Laboratory, Computer Science Department, University of California Los Angeles, CA 90095, U.S.A.
Background And Objectives: We describe and illustrate use of DISTING, a novel web application for computing alternative structurally identifiable linear compartmental models that are input-output indistinguishable from a postulated linear compartmental model. Several computer packages are available for analysing the structural identifiability of such models, but DISTING is the first to be made available for assessing indistinguishability.
Methods: The computational algorithms embedded in DISTING are based on advanced versions of established geometric and algebraic properties of linear compartmental models, embedded in a user-friendly graphic model user interface.
Addition of carvedilol to University Wisconsin solution improves rat steatotic and nonsteatotic liver preservation.
Liver Transpl
February 2010
Department of Experimental Pathology Department, Instituto de Investigaciones Biomédicas de Barcelona, CSIC, 08036 Barcelona, Spain.
Here we examine the effect of adding carvedilol (CVD) to University of Wisconsin (UW) solution on the preservation of steatotic and nonsteatotic livers during cold ischemia and after normothermic reperfusion. We used an isolated perfused rat liver model. The following protocols were evaluated.
View Article and Find Full Text PDF[The Dubin-Johnson syndrome: case report and review of literature].
Acta Gastroenterol Latinoam
September 2008
Servicio de Gastroenterología-Sección de Hepatología, Hospital Profesor Rodolfo Rossi, Ciudad de La Plata, Provincia de Buenos Aires, Argentina.
The Dubin-Johnson syndrome is a hereditary deficiency in the excretion ofconjugated bilirrubin by hepatocytes characterized by chronic hyperbilirubinemia, alteration in coproporphyrin metabolism, and intracellular deposition of a dark melanin-like pigment giving the liver a typical black cast. We report a 28-year-old male patient who presented conjunctival jaundice and conjugated-hyperbilirubinemia without no other alteration in hepatic biochemistry. The diagnosis of this syndrome was perfomed by using the low-risk methods of laparoscopy-facilitated hepatic biopsy and oral cholecystography In contrast, we avoided the classical Bromsulphalein test because of potential severe side effects.
View Article and Find Full Text PDFCholestasis induced by model organic anions protects from acetaminophen hepatotoxicity in male CD-1 mice.
Toxicol Lett
January 2006
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269-3092, USA.
Administration of the non-metabolizable organic anion indocyanine green (ICG) prior to a toxic dose of acetaminophen (4-acetamidophenol; APAP) reduces liver injury 24h after dosing. ICG also produces a dose-dependent decrease in bile flow in mice and rats. Studies in bile duct-cannulated rats suggest that cholestasis can play a role in this protection.
View Article and Find Full Text PDFSurgical treatment of hepatocellular carcinoma associated with spontaneous portosystemic shunts.
Eur J Surg
June 1999
Second Department of Surgery, Shimane Medical University, Izumo, Japan.
Objective: To clarify the short and long term prognosis after hepatectomy and shunt ligation in patients with hepatocellular carcinoma (HCC) and spontaneous portosystemic (P-S) shunts.
Design: Retrospective study.
Setting: University hospital, Japan.
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