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In Brief: Transgender, non-binary and gender-diverse patients utilizing feminizing gender-affirming hormone therapy (GAHT) may experience reduced fertility, which is currently addressed through fertility preservation and treatment cessation. Experimental research with animal models may identify mechanisms involved in testicular function impairment, their severity and duration, and may help to inform patients about reproductive health decisions.
Abstract: Feminizing GAHT may include combined estrogen, progesterone and/or antiandrogens (collectively referred to as E-GAHT) aiming to achieve individualized embodiment goals.
Soma-germline communication drives sex maintenance in the testis.
Natl Sci Rev
August 2024
Shenzhen Key Laboratory of Synthetic Genomics, Guangdong Provincial Key Laboratory of Synthetic Genomics, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
In adult gonads, disruption of somatic sexual identity leads to defective gametogenesis and infertility. However, the underlying mechanisms by which somatic signals regulate germline cells to achieve proper gametogenesis remain unclear. In our previous study, we introduced the ( ) mutant testis phenotype as a valuable model for investigating the mechanisms underlying sex maintenance.
View Article and Find Full Text PDFComplete androgen insensitivity syndrome coexisting with müllerian duct remnants: a case report and literature review.
Front Pediatr
June 2024
Department of Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
This study represents the first documentation of the coexistence of complete androgen insensitivity syndrome (CAIS) with Müllerian duct remnants (MDRs) in mainland China. Additionally, we provide a comprehensive review of the existing literature concerning CAIS with MDRs resulting from gene mutations. This study broadens the clinical spectrum of CAIS and offer novel insights for further exploration into Müllerian duct regression.
View Article and Find Full Text PDFGsdf is not indispensable for male differentiation in the medaka species Oryzias hubbsi.
Biochem Biophys Res Commun
September 2024
Laboratory of Molecular Reproductive Biology, Institute for Environmental Sciences, University of Shizuoka, Shizuoka, 422-8526, Japan; Department of Environmental Life Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, 422-8526, Japan.
Article Synopsis
- - The study explores the function of the Gonadal soma-derived growth factor (Gsdf) gene in sex determination within the medaka fish species, Oryzias hubbsi, which has a ZW sex-determination system.
- - While Gsdf shows male-dominant expression, knockout experiments indicate there’s no sex reversal and that genetic sex determination pathways remain normal without Gsdf, suggesting a different mechanism for sex differentiation in this species.
- - The loss of Gsdf results in germ cell overproliferation and quicker entry into meiosis in testes but lacks the feminizing effects seen in related species, underscoring the complexity and variability of sex determination across different fish species.
The expression profiles of cyp19a1, sf-1, esrs and gths in the brain-pituitary during gonadal sex differentiation in juvenile Japanese eels.
Gen Comp Endocrinol
July 2024
Department of Aquaculture, National Taiwan Ocean University, Keelung 202, Taiwan; Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung 202, Taiwan. Electronic address:
Eels are gonochoristic species whose gonadal differentiation initiates at the yellow eel stage and is influenced by environmental factors. We revealed some sex-related genes were sex dimorphically expressed in gonads during gonadal sex differentiation of Japanese eel (Anguilla japonica); however, the expression of sex-related genes in the brain-pituitary during gonadal sex differentiation in eels is still unclear. This study aimed to investigate the sex-related gene expressions in the brain-pituitary and tried to clarify their roles in the brain and gonads during gonadal sex differentiation.
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