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Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy.
Cell Metab
January 2025
Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:
Cellular therapies are living drugs whose efficacy depends on persistence and survival. Expansion of therapeutic T cells employs hypermetabolic culture conditions to promote T cell expansion. We show that typical in vitro expansion conditions generate metabolically and functionally impaired T cells more reliant on aerobic glycolysis than those expanding in vivo.
View Article and Find Full Text PDFDo Brazilian Olympic athletes live longer than the general population? A retrospective cohort study.
Cien Saude Colet
January 2025
Programa de Pós-Graduação em Ciências do Movimento, Grupo de Pesquisa em Exercício e Nutrição na Saúde e Rendimento Esportivo (PENSARE), Universidade Federal de Mato Grosso do Sul (UFMS). Av. Costa e Silva s/n, Cidade Universitária. 79070-900 Campo Grande MS Brasil.
We investigated if Brazilian Olympic athletes live longer than the general population, and if there are differences between the types of sport. This is a retrospective cohort study with secondary data analysis. Data from Brazilian athletes of both sexes were included, from the 7th edition (1920) to the 25th edition (1992) of the Modern Olympic Games.
View Article and Find Full Text PDFKetogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation.
Sci Adv
January 2025
Division of Molecular Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Ketogenesis is a dynamic metabolic conduit supporting hepatic fat oxidation particularly when carbohydrates are in short supply. Ketone bodies may be recycled into anabolic substrates, but a physiological role for this process has not been identified. Here, we use mass spectrometry-based C-isotope tracing and shotgun lipidomics to establish a link between hepatic ketogenesis and lipid anabolism.
View Article and Find Full Text PDFGender-Based Analysis of Injury Types and Risk Factors in Professional Tennis Players - Insights for Prevention: A Concise Review.
J Trauma Nurs
January 2025
Author Affiliations: NOVA Southeastern University, Kiran Patel College of Allopathic Medicine, Fort Lauderdale, Florida (Nunes Espat, Breeding, Nasef, and Amin); University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii (Chin); Department of Surgery, Division of Trauma and Surgical Critical Care, Orlando Regional Medical Center, Orlando, Florida (Dr Elkbuli); and Department of Surgical Education, Orlando Regional Medical Center, Orlando, Florida (Dr Elkbuli).
Background: Tennis is a globally popular sport offering physical benefits but poses a high risk of injury due to its demands and prolonged gameplay. While injuries are common among professional players, detailed injury data for this group is limited.
Objective: This review aims to analyze trends in the incidence, type, region, and onset of injuries in professional tennis players, with particular attention to gender distribution, to improve guidelines and reduce injury impacts on performance and career longevity.
Antibody response to Plasmodium vivax in the context of Epstein-Barr virus (EBV) co-infection: A 14-year follow-up study in the Amazon rainforest.
PLoS One
January 2025
Instituto René Rachou, Fiocruz Minas, Fundação Oswaldo Cruz (Fiocruz), Belo Horizonte, Minas Gerais, Brazil.
Background: To develop an effective vaccine against Plasmodium vivax, the most widely dispersed human malaria parasite, it is critical to understand how coinfections with other pathogens could impact malaria-specific immune response. A recent conceptual study proposed that Epstein-Barr virus (EBV), a highly prevalent human herpesvirus that establishes lifelong persistent infection, may influence P. vivax antibody responses.
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