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Phenytoin toxicity caused by a drug-to-drug interaction between phenytoin and antitubercular therapy.
BMJ Case Rep
January 2025
Internal Medicine, All India Institute of Medical Sciences - Rishikesh, Rishikesh, Uttarakhand, India.
Phenytoin is one of the most used antiepileptic drugs. Isoniazid, a first-line antitubercular drug, blocks the CYP2C19 enzyme, preventing phenytoin from being metabolised. Concomitant use of phenytoin and isoniazid predisposes to phenytoin toxicity.
View Article and Find Full Text PDFPreparation and characterization of oleo-gum-resin-loaded electrospun nanofibers and evaluating its wound healing activity in two rat models of skin scar and burn wound.
Front Pharmacol
November 2024
Departamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.
Background: A growing body of research is dedicated to developing new therapeutic agents for wound healing with fewer adverse effects. One of the proceedings being taken today in wound healing research is to identify promising biological materials that not only heal wounds but also vanish scarring. The effectiveness of nanofibers like polyvinyl alcohol (PVA), in improving wound healing can be related to their unique properties.
View Article and Find Full Text PDFProtocol for Therapeutic Drug Monitoring Within the Clinical Range Using Mid-infrared Spectroscopy.
Anal Chem
December 2024
School of Physics Engineering and Technology, University of York, Heslington, York YO10 5DD, U.K.
Therapeutic drug monitoring (TDM), which involves measuring drug levels in patients' body fluids, is an important procedure in clinical practice. However, the analysis technique currently used, i.e.
View Article and Find Full Text PDFThe role of candidate pharmacogenetic variants in determining valproic acid efficacy, toxicity and concentrations in patients with epilepsy.
Front Pharmacol
October 2024
Department of Neurology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Article Synopsis
- Antiseizure medications, like valproic acid (VPA), show different results in patients due to genetic factors, though there's limited research specifically on VPA compared to other drugs.
- This study aimed to analyze how genetic variations influence the effectiveness, side effects, and serum levels of VPA in patients with genetic generalized epilepsies (GGE).
- The results revealed that certain genetic variants are linked to treatment failure, increased serum levels, weight gain, and hair loss among GGE patients using VPA, suggesting a need for personalized medication approaches.
Factors associated with subtherapeutic levels of valproic acid in hospitalized patients with epilepsy: A retrospective cohort study.
Medicine (Baltimore)
November 2024
Department of Pharmacy, Sunpasitthiprasong Hospital, Ubon Ratchathani, Thailand.
Article Synopsis
- Valproic acid (VPA) is an effective and cost-effective anti-seizure medication, but maintaining proper serum levels is critical due to its narrow therapeutic window.
- A study at a hospital found that 63.2% of patients had subtherapeutic VPA levels (<50 mg/L), with factors such as male gender, previous phenytoin use, and lower dosages increasing this risk.
- Findings highlight the need for careful monitoring and personalized treatment strategies to ensure effective VPA levels, with calls for further research on minimizing the risk of subtherapeutic levels.
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