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Article Synopsis
  • - Benign tumors of the spleen are extremely rare, making up less than 0.007% of all tumors, with splenolymphangiomas being particularly uncommon and often diagnosed in children.
  • - A case study of a 58-year-old woman revealed an isolated splenic lymphangioma found during a routine checkup, which was successfully treated with laparoscopic splenectomy, showing no postoperative complications.
  • - The study emphasizes the need for early surgical intervention for large splenic lymphangiomas to prevent complications like bleeding, and suggests that laparoscopic procedures are a safe option for experienced surgeons.
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Objective: Individuals with hypopituitarism (HPs) have an increased risk of developing non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) due to growth hormone deficiency (GHD). We aimed to investigate the possible mechanisms underlying the relationship between GHD and NAFLD using proteomic and metabolomic insights.

Methods: Serum metabolic alternations were assessed in male HPs using untargeted metabolomics.

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Acromegaly in humans and cats: Pathophysiological, clinical and management resemblances and differences.

Growth Horm IGF Res

June 2024

Pituitary Tumor Unit, Endocrinology Department, Hospital CUF Descobertas, Lisbon, Portugal; Faculdade de Medicina, Universidade Católica Portuguesa, Lisbon, Portugal. Electronic address:

Article Synopsis
  • Acromegaly is a disorder caused by excess growth hormone (GH) and insulin-like growth factor-1 (IGF-1), leading to distinct physical changes and various health complications in both humans and cats.
  • A literature review highlighted similarities and differences in how acromegaly manifests in these species, including craniofacial changes, joint issues, and cardiometabolic risks.
  • Both species experience growth-related problems and associated diseases, but unique symptoms like human-specific skin conditions and different physical changes in cats distinguish their presentations.
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Key Clinical Message: Our case highlights the importance of recognizing acromegaly as a potential risk factor for venous thromboembolism (VTE). Despite a thorough thrombophilia workup yielding unremarkable results, further research is warranted to elucidate the underlying mechanisms linking acromegaly and thrombophilia. This understanding will aid in improving risk assessment and management strategies for patients with acromegaly.

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Article Synopsis
  • Functioning gonadotroph adenomas are rare tumors that secrete excess follicle-stimulating hormone (FSH) and often lead to sexual dysfunction and other symptoms before being diagnosed.
  • A case study highlighted a 37-year-old male with FSH-secreting macroadenoma who experienced sexual difficulties, testicular issues, and later headaches and visual problems, ultimately diagnosed through imaging and hormonal tests.
  • The patient underwent successful surgery, resulting in significant improvement in hormone levels and symptoms, underlining the importance of considering rare pituitary disorders in patients with atypical hypogonadal symptoms.
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