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N exchanges in hyperbaric environments: towards a model based on physiological gas transport (O and CO).
J Appl Physiol (1985)
November 2024
ORPHY Laboratory, Université de Brest, 6 Avenue Le Gorgeu, 29238 Brest, France.
Decompression sickness can occur in divers even when recommended decompression procedures are followed. Furthermore, the physiological state of individuals can significantly affect bubbling variability. These informations highlight the need for personalized input to improve decompression in SCUBA diving.
View Article and Find Full Text PDFDeciphering Alveolo-Capillary Gas Transfer Disturbances in Patients Recovering from COVID-19 Lung Disease.
J Pers Med
July 2024
Lung Function & Respiratory Physiology Unit, Department of Respiratory Physiology and Sleep Medicine, Assistance Publique-Hôpitaux de Paris, Cochin Hospital, University Paris Cité, 75006 Paris, France.
Impaired lung gas exchange is commonly seen in patients with pulmonary involvement related to SARS-CoV-2 acute infection or post-acute COVID-19 syndrome (PACS). The primary aim of our study was to assess lung gas transfer, measuring the pulmonary diffusion capacity for nitric oxide (D) and carbon monoxide (D) in all COVID-19 patients. Our secondary aim was to decipher the respective roles of perturbed lung membrane conductance (D) and reduced pulmonary capillary volume (V) in patients with impaired lung gas exchange.
View Article and Find Full Text PDFAlveolar cytokines and interferon autoantibodies in COVID-19 ARDS.
Front Immunol
April 2024
Department of Anesthesiology and Intensive Care, Copenhagen University Hospital-Amager and Hvidovre Hospitals, Hvidovre, Denmark.
Background: Type I interferon (IFN-I) and IFN autoantibodies play a crucial role in controlling SARS-CoV-2 infection. The levels of these mediators have only rarely been studied in the alveolar compartment in patients with COVID-19 acute respiratory distress syndrome (CARDS) but have not been compared across different ARDS etiologies, and the potential effect of dexamethasone (DXM) on these mediators is not known.
Methods: We assessed the integrity of the alveolo-capillary membrane, interleukins, type I, II, and III IFNs, and IFN autoantibodies by studying the epithelial lining fluid (ELF) volumes, alveolar concentration of protein, and ELF-corrected concentrations of cytokines in two patient subgroups and controls.
Endothelial TRPV4 channels in lung edema and injury.
Curr Top Membr
October 2022
Department of Surgery, University of Virginia, Charlottesville, VA, United States.
The alveolo-capillary barrier is relatively impermeable, and facilitates gas exchange via the large alveolar surface in the lung. Disruption of alveolo-capillary barrier leads to accumulation of edema fluid in lung injury. Studies in animal models of various forms of lung injury provide evidence that TRPV4 channels play a critical role in disruption of the alveolo-capillary barrier and pathogenesis of lung injury.
View Article and Find Full Text PDFNebulized Colistin in Ventilator-Associated Pneumonia and Tracheobronchitis: Historical Background, Pharmacokinetics and Perspectives.
Microorganisms
May 2021
Multidisciplinary Intensive Care Unit, Department of Anaesthesiology and Critical Care, La Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, Medicine Sorbonne University, 75012 Paris, France.
Clinical evidence suggests that nebulized colistimethate sodium (CMS) has benefits for treating lower respiratory tract infections caused by multidrug-resistant Gram-negative bacteria (GNB). Colistin is positively charged, while CMS is negatively charged, and both have a high molecular mass and are hydrophilic. These physico-chemical characteristics impair crossing of the alveolo-capillary membrane but enable the disruption of the bacterial wall of GNB and the aggregation of the circulating lipopolysaccharide.
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