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Phase 1 Mass Balance Study of Pizuglanstat: An Investigational Hematopoietic Prostaglandin D Synthase Inhibitor.
Clin Pharmacol Drug Dev
January 2025
Taiho Pharmaceutical Co., Ltd., Tokyo, Japan.
Pizuglanstat is a novel hematopoietic prostaglandin D synthase inhibitor and investigational treatment for Duchenne muscular dystrophy. This Phase 1 mass balance study aimed to characterize the absorption, metabolism, and excretion of carbon-14 (C)-labeled pizuglanstat in healthy adults (ClinicalTrials.gov, NCT04825431).
View Article and Find Full Text PDFDiagnosis and treatment of hepatocellular carcinoma with pelvic metastasis expressing AFP: a case report.
Front Oncol
January 2025
Department of Vascular Intervention, Shengli Oilfield Central Hospital, Dongying, Shandong, China.
This report presents the case of a 68-year-old female patient with hepatocellular carcinoma (HCC) who experienced persistently elevated alpha-fetoprotein (AFP) levels following resection of the primary liver tumor. The patient had previously undergone transcatheter arterial chemoembolization (TACE) and liver tumor resection, but postoperative AFP levels continued to rise, suggesting the possibility of extrahepatic metastasis. PET-CT scans revealed an irregular soft tissue mass in the recto-uterine pouch, which was later confirmed as a HCC metastasis through needle biopsy.
View Article and Find Full Text PDFPrognostic Indicators and Comparative Treatment Outcomes in High-Risk Thyroid Cancer with Laryngotracheal Invasion.
Endocrinol Metab (Seoul)
January 2025
Department of Surgery, School of Medicine, Tulane University, New Orleans, LA, USA.
Background: Laryngotracheal invasion occurs in a subset of patients with well-differentiated thyroid cancer (WDTC) and is associated with a poor prognosis. We aimed to analyze patterns and predictors/outcomes related to this high-risk manifestation.
Methods: This population-based analysis utilized the Surveillance, Epidemiology, and End Results (SEER) registry (2000 to 2015) to identify WDTC patients.
Integral cross section measurement of the F( γ, n)F reaction for 12-20 MeV bremsstrahlung photons.
Appl Radiat Isot
January 2025
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India.
F radioactive isotope is widely used in PET imaging for nuclear medicine. Medical linear accelerators producing high-flux bremsstrahlung beams up to 20 MeV are commonly used in radiation therapy. Hence, the production of F through photon-induced channels will reduce many of the intricacies in transportation and handling.
View Article and Find Full Text PDFEfficient capture of TcO/ReO via node and linker bifunctional anion exchange covalent organic frameworks.
J Hazard Mater
January 2025
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China. Electronic address:
In nuclear wastewater treatment, ion-scavenging materials designed to trap TcO is urgently needed. However, strong acid/base, high radiation and high salt concentration of nuclear wastewater usually result in inadequate stability and adsorption capacity of the adsorbent. Herein, we report a new class of bifunctional anion-exchange olefin-linked COF (BPDC-MTMP) prepared via Knoevenagel condensation reactions, the first example exploring the synergistic integration of positively charged fragments at both nodes and linkers.
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