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Accounting for microorganisms yields stricter water quality criteria and elevated ecological risks of antibiotics: A case study of sulfonamides in the Yangtze River Delta.
Ecotoxicol Environ Saf
January 2025
School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China. Electronic address:
The derivation of water quality criteria (WQC) for antibiotics is influenced by the inclusion of various organisms' toxicity data, including microbial data, though no definitive conclusions have been reached. This study focuses on sulfonamide antibiotics, common in the Yangtze River Delta (YRD), to assess the influences of different organisms' toxicity data on determining WQCs and subsequent evaluation of ecological risks. A total of 263 toxicity data points from eight sulfonamides, including sulfamethoxazole (SMX) and sulfamethazine (SM2), were selected to derive WQCs using Species Sensitivity Distribution (SSD) methods.
View Article and Find Full Text PDFA competitive dual-mode for tetracycline antibiotics sensing based on colorimetry and surface-enhanced Raman scattering.
Biosens Bioelectron
December 2024
State Key Laboratory of Food Science and Resources, School of Food Science and Technology, Jiangnan University, 214122, Wuxi, Jiangsu, People's Republic of China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, 214122, Wuxi, Jiangsu, People's Republic of China; International Joint Laboratory on Food Safety, Jiangnan University, 214122, Wuxi, Jiangsu, People's Republic of China. Electronic address:
Tetracycline antibiotics (TCs) are extensively used as broad-spectrum antimicrobials. However, their excessive use and misuse have led to serious accumulation in foods and environments, posing a significant threat to human health. To solve such public issue, we have designed a novel dual-mode detection method, integrating colorimetric sensing with surface-enhanced Raman scattering (SERS) technology, for sensitive and rapid evaluation on TCs.
View Article and Find Full Text PDFNanoparticle-mediated light-driven LAMP combined with test strips for sensitive and rapid visual detection of antibiotic resistance genes.
J Hazard Mater
December 2024
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; International Joint Laboratory on Food Safety, Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address:
Antibiotic resistance genes (ARGs) are markers of drug-resistant pathogens, monitoring them contributes to prevent resistance to drugs. The detection methods for ARGs including PCR and isothermal amplification are sensitive and selective. However, it may take several hours or cannot be used on spot.
View Article and Find Full Text PDFSmall molecules targeting the eubacterial β-sliding clamp discovered by combined and screening approaches.
J Enzyme Inhib Med Chem
December 2025
Laboratory of Biochemistry and Molecular Biology, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy.
Antibiotic resistance stands as the foremost post-pandemic threat to public health. The urgent need for new, effective antibacterial treatments is evident. Protein-protein interactions (PPIs), owing to their pivotal role in microbial physiology, emerge as novel and attractive targets.
View Article and Find Full Text PDFEmerging Antifungal Resistance in : Insights from Susceptibility Profiling and Genetic Mutation Analysis.
Emerg Microbes Infect
January 2025
Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China.
species, the leading cause of dermatophytosis globally, are increasingly resistant to antifungal treatments, concerns about effective management strategies. In light of the absence of established resistance criteria for terbinafine and azoles, coupled with a dearth of research on resistance mechanisms in , antifungal susceptibility and drug resistance gene diversity were analyzed across 64 , 65 , and 2 isolates collected in China between 2001 and 2024 and 101 published strains. Analyses of the minimum inhibitory concentrations (MICs) of terbinafine, itraconazole, voriconazole, posaconazole, and isavuconazole revealed a concerning increase in with terbinafine resistance, including two novel isolates from China.
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