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Short- and long-term pathologic responses to quartz are induced by nearly free silanols formed during crystal fracturing.
Part Fibre Toxicol
December 2024
Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain (UCLouvain), Brussels, Belgium.
Article Synopsis
- - The inhalation of respirable crystalline silica, particularly quartz, is linked to serious health issues like lung inflammation, fibrosis, cancer, and autoimmune diseases, with nearly free silanols (NFS) from fractured quartz being key players in this toxicity.
- - Experiments on mice showed that exposure to NFS-rich quartz caused significant acute and long-term inflammatory responses, fibrosis, cancer, and autoimmune signs, while NFS-poor quartz showed no such effects.
- - The study highlights that NFS-rich quartz specifically triggers harmful biological responses, including increased pro-inflammatory cytokines, lung fibrosis markers, tumors, and autoantibodies, underscoring its health risks compared to less reactive quartz forms.
Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation.
Acta Pharm Sin B
September 2021
Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates with the occurrence and progression of ulcerative colitis. Although targeting NLRP3 inflammasome has been considered to be a potential therapy, the underlying mechanism through which pathway the intestinal inflammation is modulated remains controversial. By focusing on the flavonoid lonicerin, one of the most abundant constituents existed in a long historical anti-inflammatory and anti-infectious herb Thunb.
View Article and Find Full Text PDFThe formation of g=2.49-species of cytochrome P450 in the rat liver by PCB126 oral administration: identification of heme axial ligands by EPR spectroscopy.
Biosci Biotechnol Biochem
December 2006
School of Veterinary Medicine, Azabu University, Sagamihara.
Rat livers and microsomes were subjected to electron paramagnetic resonance (EPR) measurements at 77 K. The EPR spectra of the livers from the control group, carbon tetrachloride-, 3-methylcholanthrene-, and 3,3',4,4',5-pentachlorobiphenyl (PCB126)-treated rats exhibited an EPR spectrum at g=2.40, 2.
View Article and Find Full Text PDFInhibitory effects of adrenomedullary hormone on the induction and growth of fibrosarcoma by methylcholanthrene.
Neuro Endocrinol Lett
April 2005
Department of Anatomy, Hirosaki University School of Medicine, Zaifucho 5, Hirosaki 036-8562, Japan.
Objective: Effects of adrenomedullary hormone(s) on the induction and growth of fibrosarcoma by methylcholanthrene (MC) were examined.
Methods: At 28 days of age, male Wistar rats were divided into four groups: 1) control, 2) bilateral adrenomedullectomy (Bil. AMX), 3) right AMX + left adrenomedullary autotransplantation (AMX + AMT), 4) Bil.
Molecular modelling of CYP1A subfamily members based on an alignment with CYP102: rationalization of CYP1A substrate specificity in terms of active site amino acid residues.
Xenobiotica
July 1996
School of Biological Sciences, University of Surrey, Guildford, UK.
1. Using a novel amino acid sequence alignment, proteins of the CYP1A subfamily have been produced from the CYP102 crystal structure template via residue replacement and energy minimization procedures. 2.
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