The necropsy findings of 85 cats that died up to six weeks after administration of injectable anaesthetics are described. The most obvious findings in these cats were degeneration and necrosis of heart muscle fibres followed and related to time after the administration of the anaesthetics, by infiltration of predominantly mononuclear cells and by an increase in collagenous connective tissue. The lesions were most obvious on the inner side of the myocardium, indicating that hypoxic injury occurred during anaesthesia. The possible mechanism of the damage to the heart and its role in the pathogenesis of cardiomyopathy in the cat is discussed.
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