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Building a growing genomic repository for maternal and fetal health through the PING Consortium.
Pediatr Res
January 2025
Center for Genetic Medicine, Children's National Research Institute, Washington, DC, USA.
Background: Prenatally transmitted viruses can cause severe damage to the developing brain. There is unexplained variability in prenatal brain injury and postnatal neurodevelopmental outcomes, suggesting disease modifiers. Of note, prenatal Zika infection can cause a spectrum of neurodevelopmental disorders, including congenital Zika syndrome.
View Article and Find Full Text PDFFXR1 Deletion from Cortical Parvalbumin Interneurons Modifies their Excitatory Synaptic Responses.
eNeuro
January 2025
Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, 53705
Fragile X autosomal homolog 1 (FXR1), a member of the fragile X messenger riboprotein 1 family, has been linked to psychiatric disorders including autism and schizophrenia. Parvalbumin (PV) interneurons play critical roles in cortical processing, and have been implicated in FXR1-linked mental illnesses. Targeted deletion of FXR1 from PV interneurons in mice has been shown to alter cortical excitability and elicit schizophrenia-like behavior.
View Article and Find Full Text PDFIntegrating crowdsourced data in the built environment studies: A systematic review.
J Environ Manage
January 2025
Department of Landscape Architecture, University of Nevada, Las Vegas, NV, USA. Electronic address:
The integration of crowdsourced data has become central to contemporary built environment studies, driven by the rapid growth in digital technologies and participatory approaches that characterize modern urbanism. Despite its potential, a systematic framework for its analysis remains underdeveloped. This review, conducted in accordance with the PRISMA protocol, examines the use of crowdsourced data in shaping the built environment, scrutinizing its applications, crowdsourcing techniques, methodologies, and comparison with other big data forms.
View Article and Find Full Text PDFA Qualitative Analysis of Family Caregiver Experiences Accessing Treatment for Self-Injurious Behavior in Individuals with Intellectual and Developmental Disabilities.
J Ment Health Res Intellect Disabil
June 2023
Department of Educational Psychology, University of Minnesota.
Introduction: There is evidence of a gap between individuals with intellectual and developmental disabilities (IDD) who need treatment for self-injurious behavior (SIB) and those who receive treatment. The purpose of this study (=15) was to begin to understand the treatment gap from the perspective of family caregivers.
Methods: In semi-structured virtual interviews, family caregivers discussed their experiences of working with providers to treat their child's or sibling's self-injury.
Evolution takes multiple paths to evolvability when facing environmental change.
Proc Natl Acad Sci U S A
January 2025
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109.
Life at all scales is surprisingly effective at exploiting new opportunities, as demonstrated by the rapid emergence of antimicrobial resistance and novel pathogens. How populations acquire this level of evolvability and the various ways it aids survival are major open questions with direct implications for human health. Here, we use digital evolution to show that changing environments facilitate the simultaneous evolution of high mutation rates and a distribution of mutational effects skewed toward beneficial phenotypes.
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