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Exploring the potential mechanism of atrazine-induced dopaminergic neurotoxicity based on integration strategy.
Environ Health Prev Med
September 2024
Department of Occupational and Environmental Health, College of Public Health, Xuzhou Medical University.
Article Synopsis
- Atrazine (ATR), a widely used herbicide, is linked to neurotoxic effects that may mirror symptoms of Parkinson's disease, prompting this study to explore the underlying molecular mechanisms.
- The research utilized network toxicology and various analytical methods to identify key protein targets involved in ATR-induced dopaminergic injury, ultimately identifying five significant hub targets.
- The findings suggested that these targets are crucial in ATR's neurotoxic effects, indicating a need for deeper exploration into ATR's molecular toxicity mechanisms.
Peripheral dopamine suppression and elevated cystatin C in early diabetic nephropathy in spontaneously diabetic rats.
Am J Physiol Renal Physiol
October 2024
Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan.
Article Synopsis
- Intrarenal dopamine helps protect against diabetic nephropathy in early-stage diabetes by reducing glomerular hyperfiltration, oxidative stress, inflammation, and fibrosis in mice models.
- The study used benserazide to investigate the effects of peripheral dopamine on kidney function in spontaneously diabetic Torii rats, showing that lower peripheral dopamine levels worsen renal dysfunction.
- Findings reveal that peripheral dopamine plays a crucial role in controlling oxidative stress and kidney performance during the early stages of diabetic nephropathy, evidenced by its effect on markers of renal dysfunction.
Noradrenaline and Adrenoreceptors Are Involved in the Regulation of Prostaglandin I2 Production in the Porcine Endometrium after Experimentally Induced Inflammation.
Int J Mol Sci
June 2024
Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-718 Olsztyn, Poland.
Endometritis is a common disease in animals, leading to disruption of reproductive processes and economic losses. Noradrenergic control of prostaglandin (PG)I2 formation by inflamed endometrium is unknown. We determined the involvement of α1-, α2- and β-adrenoreceptors (ARs) in noradrenaline-influenced PGI synthase (PGIS) protein abundance and PGI2 release from porcine (1) endometrial explants with ()-induced inflammation in vivo, and (2) lipopolysaccharide (LPS)-treated endometrial epithelial cells.
View Article and Find Full Text PDFCollaborative action between noradrenergic and serotoninergic systems in peripheral antinociception in mice.
J Biosci
June 2024
Department of Pharmacology, Institute of Biological Sciences, UFMG, Av. Antoˆ nio Carlos, 31.270-100, Belo Horizonte 6627, Brazil.
Noradrenaline (NA) and serotonin (5-HT) induce nociception and antinociception. This antagonistic effect can be explained by the dose and type of activated receptors. We investigated the existence of synergism between the noradrenergic and serotonergic systems during peripheral antinociception.
View Article and Find Full Text PDFDiabetes and obesity: the role of stress in the development of cancer.
Endocrine
October 2024
Department of Medicine.(DIMED), Unit of Metabolic Disease, University of Padova University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
Diabesity is a condition where an individual has both diabetes and obesity, which can lead to severe complications including cardiovascular disease, a leading cause of mortality. Recently, cancer has become a leading cause of excess hospitalizations, and both diabetes and obesity are associated with a higher risk of developing several types of cancer. In this review, we propose that chronic stress significantly increases this association.
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