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Photocatalytic Multiple Deuteration of Polyethylene Glycol Derivatives using Deuterium Oxide.
Chemistry
December 2024
Osaka University, Graduate School of Pharmaceutical Sciences, 1-6, Yamada-oka, 565-0871, Osaka, JAPAN.
Deuterated molecules are of growing interest because of the specific characteristics of deuterium, such as stronger C-D bonds being stronger than C-H bonds. Polyethylene glycols (PEGs) are widely utilized in scientific fields (e.g.
View Article and Find Full Text PDFDeuterated water (HO) can be used to quantify hemoglobin synthesis and red blood cell lifespan in humans.
Acta Physiol (Oxf)
December 2024
Human Performance Lab, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.
The Deuterium Oxide Dilution Method to Quantify Human Milk Intake Volume of Infants: A Systematic Review-A Contribution from the ConcePTION Project.
Nutrients
December 2024
Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
Article Synopsis
- Global health organizations support breastfeeding, but maternal medication can complicate this due to safety concerns about drug transfer through breast milk.
- A systematic review was conducted to gather and analyze data on human milk intake volume using deuterium oxide dilution, comparing results with existing literature and exploring maternal factors that may affect milk intake.
- The review included 60 studies from 34 countries involving over 5,500 infants, revealing that maternal smoking reduced milk intake, while a logarithmic regression model was developed to better understand milk intake changes based on the infant's postnatal age, highlighting the need for more data on early infancy for improved pharmacokinetic modeling.
Exploring Infant Size and Body Composition at 18 Months: An Ambidirectional Peri-Urban South African Cohort Study.
Matern Child Nutr
December 2024
Department of Paediatrics, University of Pretoria, Pretoria, South Africa.
Article Synopsis
- The study investigates how prenatal, perinatal, and postnatal factors influence infant growth and body composition at 18 months in a South African peri-urban setting.
- Key findings indicate that higher umbilical artery resistance predict lower birth weights and shorter lengths, while maternal HIV status and household food insecurity are associated with poorer growth indicators.
- The research highlights the significant impact of early nutrition and health on long-term developmental outcomes, stressing the importance of addressing these factors to improve child health and prevent stunting.
Divergent Molecular Responses to Heavy Water in Compared to Bacteria and Yeast.
Plants (Basel)
November 2024
Department of Molecular Biology and Radiobiology, Faculty of AgriSciences, Mendel University in Brno, 61300 Brno, Czech Republic.
Heavy water (DO) is scarce in nature, and despite its physical similarity to water, DO disrupts cellular function due to the isotope effect. While microbes can survive in nearly pure DO, eukaryotes such as are more sensitive and are unable to survive higher concentrations of DO. To explore the underlying molecular mechanisms for these differences, we conducted a comparative proteomic analysis of , , and after 180 min of growth in a DO-supplemented media.
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