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Subgroups varying in risk and density highlight the potential for stratified breast cancer screening.
Eur J Cancer
January 2025
Department of Public Health, Erasmus MC, Rotterdam, the Netherlands.
Most breast cancer screening programs rely only on demographic data without considering individual risk factors of the population, which might limit their effectiveness by over- and underscreening specific subgroups. Therefore, the aim of this study is to highlight health and economic disparities in outcomes from such a uniform screening strategy. With the microsimulation model MISCAN, we simulated outcomes of the Dutch screening program considering 16 subgroups varying by their 5-year breast cancer risk and breast density.
View Article and Find Full Text PDFConstruction and evaluation of a multifactorial clinical model for discriminating benign and malignant breast tumors using LASSO algorithm based on retrospective cohort study.
Am J Cancer Res
December 2024
Department of Breast Surgery, Huangpu Branch, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine Shanghai 200011, China.
Breast cancer is one of the malignant tumors that seriously threaten women's health, and early diagnosis and detection of breast cancer are crucial for effective treatment. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an important diagnostic tool that allows for the dynamic observation of blood flow characteristics of breast tumors, including small lesions within the affected tissue. Currently, it is widely used in clinical practice and has been shown promising prospects.
View Article and Find Full Text PDFTriple-Negative Breast Cancer: Radiologic-Pathologic Correlation.
J Breast Imaging
January 2025
Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Triple-negative breast cancers (TNBCs) are invasive carcinomas that lack ER and PR expression and also lack amplification or overexpression of HER2. Triple-negative breast cancers are histopathologically diverse, with the majority classified as invasive breast carcinomas of no special type with a basal-like profile. Triple-negative breast cancer is the most aggressive molecular subtype of invasive breast carcinoma, with the highest rates of stage-matched mortality and regional recurrence.
View Article and Find Full Text PDFThe impact of the BreastScreen NSW transition from film to digital mammography, 2002-2016: a linked population health data analysis.
Med J Aust
January 2025
Sydney School of Public Health, the University of Sydney, Sydney, NSW.
Objectives: To assess the impact of the transition from film to digital mammography in the Australian national breast cancer screening program.
Study Design: Retrospective linked population health data analysis (New South Wales Central Cancer Registry, BreastScreen NSW); interrupted time series analysis.
Setting: New South Wales, 2002-2016.
A Radiomic-Clinical Model of Contrast-Enhanced Mammography for Breast Cancer Biopsy Outcome Prediction.
Acad Radiol
January 2025
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213 (C.L., S.W.); Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 (D.A., M.Z., J.S., S.W.); Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15213 (S.W.); Intelligent Systems Program, University of Pittsburgh, Pittsburgh, PA 15213 (S.W.). Electronic address:
Rationale And Objectives: In the USA over 1 million breast biopsies are performed annually. Approximately 9.6% diagnostic exams were given Breast Imaging Reporting and Data System (BI-RADS) ≥4A, most of which are 4A/4B.
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