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Probiotics ameliorates hypothalamic amenorrhea in a rat model of PCOS.
Metab Brain Dis
March 2025
Cardio/Endo-Metabolic and Epigenetics Research Unit, Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, 360101, Nigeria.
Background: Polycystic ovary syndrome (PCOS) is a common endocrinometabolic disorder affecting women of reproductive age, characterized by hormonal imbalances, irregular menstrual cycles, and often, infertility. Hypothalamic amenorrhea, a condition marked by the cessation of menstruation due to disruptions in the hypothalamic-pituitary-gonadal axis, is a frequent manifestation in PCOS. Probiotics, beneficial microorganisms known for improving metabolic health, have shown promise in restoring hormonal balance and enhancing fertility.
View Article and Find Full Text PDFGut microbiome-driven regulation of sex hormone homeostasis: a potential neuroendocrine connection.
Gut Microbes
December 2025
Department of Nutrition Science, Purdue University, West Lafayette, IN, USA.
The gut microbiome is known to have a bidirectional relationship with sex hormone homeostasis; however, its role in mediating interactions between the primary regulatory axes of sex hormones and their productions is yet to be fully understood. We utilized both conventionally raised and gnotobiotic mouse models to investigate the regulatory role of the gut microbiome on the hypothalamic-pituitary-gonadal (HPG) axis. Male and female conventionally raised mice underwent surgical modifications as follows: (1) hormonally intact controls; (2) gonadectomized males and females; (3) gonadectomized males and females supplemented with testosterone and estrogen, respectively.
View Article and Find Full Text PDFLong-term consumption of green tea protects the mental health of middle-aged and older adult men by improving inflammation levels.
Front Public Health
March 2025
Jingshan Psychiatric Hospital, Jingmen, Hubei, China.
Background: Middle-aged and older adult men are at a heightened risk of depression. Green tea, as a popular beverage, has drawn widespread attention for its health benefits. However, there remains controversy over the effects of green tea on combating depression and regulating hormones.
View Article and Find Full Text PDFHormone correction of dysfunctional metabolic gene expression in stem cell-derived liver tissue.
Stem Cell Res Ther
March 2025
Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, EH16 4UU, UK.
The increase in metabolic dysfunction-associated steatotic liver disease (MASLD) and its progression to metabolic dysfunction-associated steatohepatitis (MASH) is a worldwide healthcare challenge. Heterogeneity between men and women in the prevalence and mechanisms of MASLD and MASH is related to differential sex hormone signalling within the liver, and declining hormone levels during aging. In this study we used biochemically characterised pluripotent stem cell derived 3D liver spheres to model the protective effects of testosterone and estrogen signalling on metabolic liver disease 'in the dish'.
View Article and Find Full Text PDFPubertal induction therapy in pediatric patients with Duchenne muscular dystrophy.
J Pediatr Endocrinol Metab
March 2025
Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Objectives: We conducted a scoping review and analyzed the medical literature on PubMed to assess any potential short-term and long-term benefits of pubertal induction in patients with DMD.
Content: We identified six articles from our research cumulatively reporting clinical data from 58 pediatric patients with DMD, of age between 12 and 17.7 years.
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